Systemic HypertensionSystemic HypertensionСистемные гипертензии2075-082X2542-2189Intermedservice Ltd2918410.26442/SG29184ArticlesСтатьиReview ArticleDihydropyridine calcium antagonists: conscious choiceДигидропиридиновые антагонисты кальция: осознанный выборOstroumovaO DОстроумоваО Д

д-р мед. наук, проф. каф. факультетской терапии и профболезней ФГБОУ ВО «МГМСУ им. А.И.Евдокимова», проф. каф. клинической фармакологии и пропедевтики внутренних болезней ФГАОУ ВО «Первый МГМУ им. И.М.Сеченова»

ostroumova.olga@mail.ruVikentevV VВикентьевВ В

канд. мед. наук, доц. каф. факультетской терапии и профболезней ФГБОУ ВО «МГМСУ им. А.И.Евдокимова»

vvvikentiev@mail.ruAbrosimovA GАбросимовА Г

канд. мед. наук, доц. каф. клинической фармакологии и пропедевтики внутренних болезней ФГАОУ ВО «Первый МГМУ им. И.М.Сеченова»

SmoliarchukE AСмолярчукЕ А

канд. мед. наук, доц. каф. клинической фармакологии и пропедевтики внутренних болезней ФГАОУ ВО «Первый МГМУ им. И.М.Сеченова»

smolyarchuk@mail.ruA.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian FederationФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И.Евдокимова» Минздрава РоссииI.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationФГАОУ ВО «Первый Московский государственный университет им. И.М.Сеченова» Минздрава России15032017141VOL 14, NO1 (2017)ТОМ 14, №1 (2017)616809042020Copyright ©; 2017, Consilium MedicumCopyright ©; 2017, ООО "Консилиум Медикум"2017Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://journals.eco-vector.com/2075-082X/article/view/29184

This article contains information concerning the aspects of pharmacokinetics and pharmacodynamics of dihydropyridine calcium antagonists. The authors have discussed the evidence-based amlodipine treatment of arterial hypertension, ischemic heart disease and chronic heart failure. The authors present the comparison of the efficacy, safety and application characteristics of the different dihydropyridine calcium antagonists that can be used in specific clinical cases.

В статье приведены данные об особенностях фармакокинетики и фармакодинамики дигидропиридиновых антагонистов кальция. Рассмотрена доказательная база амлодипина в лечении артериальной гипертонии, ишемической болезни сердца, хронической сердечной недостаточности. Проведено сравнение эффективности, безопасности и особенностей применения в особых клинических ситуациях отдельных представителей класса дигидропиридиновых антагонистов кальция.

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