Systemic HypertensionSystemic HypertensionСистемные гипертензии2075-082X2542-2189Intermedservice Ltd2960710.26442/2075-082X_2018.2.55-59ArticlesСтатьиResearch ArticleStroke prevention in patients with atrial fibrillation and comorbiditiesПрофилактика инсульта у пациента с фибрилляцией предсердий и сопутствующими заболеваниямиOstroumovaO DОстроумоваОльга Дмитриевна

д-р мед. наук, проф. каф. факультетской терапии и профболезней, проф. каф. клинической фармакологии и пропедевтики внутренних болезней

ostroumova.olga@mail.ruVoevodinaN YuВоеводинаНадежда Юрьевна

канд. мед. наук, зам. глав. врача по медицинской части

gkb-mukhina@zdrav.mos.ruGusevaT FГусеваТатьяна Федоровна

канд. мед. наук, доц. каф. факультетской терапии и профболезней

tguseva65@mail.ruPavleevaE EПавлееваЕлена Евгеньевна

канд. мед. наук, ассистент каф. пропедевтики внутренних болезней и гастроэнтерологии

pavleeva.elena@mail.ruPiksinaG FПиксинаГалина Федоровна

канд. мед. наук, врач-кардиолог, зав. первым кардиологическим отд-нием

galina-piksina@yandex.ruGoloborodovaI VГолобородоваИрина Васильевна

канд. мед. наук, доц. каф. факультетской терапии и профболезней

giv55555@ramler.ruA.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian FederationФГБОУ ВО «МГМСУ им. А.И.Евдокимова», ФГАОУ ВО «Первый МГМУ им. И.М.Сеченова»I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationГБУЗ «ГКБ им. Е.О.Мухина»E.O.Muhin City Clinical Hospital of the Department of Health of MoscowФГБОУ ВО «МГМСУ им. А.И.Евдокимова»A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian FederationФГБОУ ВО «МГМСУ им. А.И.Евдокимова»A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian FederationГБУЗ «ГКБ им. Е.О.Мухина»A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation15062018152VOL 15, NO2 (2018)ТОМ 15, №2 (2018)555909042020Copyright ©; 2018, Consilium MedicumCopyright ©; 2018, ООО "Консилиум Медикум"2018Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://journals.eco-vector.com/2075-082X/article/view/29607

In the article questions of prevention of stroke, including repeated ones, are considered. The choice of anticoagulant therapy is discussed in patients with atrial fibrillation and a number of concomitant diseases - coronary artery disease, diabetes mellitus, chronic kidney disease, chronic heart failure. The data of subanalyses of a randomized clinical trial of ARISTOTLE are presented, indicating a high profile of efficacy and safety of the new oral anticoagulant apixaban in these categories of patients.

В статье рассмотрены вопросы профилактики инсульта, в том числе повторного. Обсуждается выбор антикоагулянтной терапии у больных с фибрилляцией предсердий и рядом сопутствующих заболеваний - ишемической болезнью сердца, сахарным диабетом, хронической болезнью почек, хронической сердечной недостаточностью. Приведены данные субанализов рандомизированного клинического исследования ARISTOTLE, свидетельствующие о высоком профиле эффективности и безопасности нового орального антикоагулянта апиксабана у данных категорий больных.

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