Phase angle as an early marker of sarcopenia
- Authors: Sokolova A.V.1,2, Dragunov D.O.1,2, Arutyunov G.P.1, Toporkova E.V.1, Suleymanova D.R.1, Abdusalyamova S.R.1, Skripachuk D.I.1
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Affiliations:
- Pirogov Russian National Research Medical University
- Research Institute for Healthcare Organization and Medical Management, Moscow Healthcare Department
- Issue: Vol 18, No 1 (2026)
- Pages: 38-43
- Section: Original Articles
- Published: 11.03.2026
- URL: https://journals.eco-vector.com/2075-3594/article/view/704043
- DOI: https://doi.org/10.18565/nephrology.2026.1.38-43
- ID: 704043
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Abstract
Objective. Evaluation of the relationship between phase angle (PA) and sarcopenia indicators in patients with chronic heart failure (CHF) and chronic kidney disease (CKD).
Materials and methods. The study included 144 patients with CHF and CKD, of whom 46 (32%) had no signs of sarcopenia (Group 1), 62 (43%) were diagnosed with presarcopenia (Group 2), and 36 (25%) with established sarcopenia (Group 3). In the overall sample, the mean age was 68.04±9.72 years.
Results. The PA significantly differed between the groups: the median PA increased from the non-sarcopenic to the sarcopenic group (p=0.0017), with pairwise differences between groups 1–3 (p=0.0007) and 2–3 (p=0.024), and a trend between 1–2 (p=0.059). Correlation analysis revealed associations between muscle status and nutritional and renal parameters: skeletal muscle mass correlated with albumin (p=0.61; p=0.015) and creatinine (p=0.29; p=0.004), PA - with glomerular filtration rate (GFR) (p=0.38; p=0.00016), and shoulder muscle area with GFR (p=0.43; p=0.0006) and C-reactive protein (p=-0.62; p=0.002), indicating a link between deteriorating kidney function and inflammation with muscle degradation and the severity of sarcopenia.
Conclusion. PA significantly differs in patients with CHF and CKD depending on sarcopenic status (p< 0.001). PA can be considered as a promising indicator for early screening and risk stratification of sarcopenia.
About the authors
Anna V. Sokolova
Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical Management, Moscow Healthcare Department
Author for correspondence.
Email: Sokolova2211@gmail.com
ORCID iD: 0000-0003-0823-9190
Cand.Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine,, Pirogov Russian National Research Medical University (Pirogov University); Leading Specialist, Organizational and Methodological Department for Therapy, Research Institute of Healthcare and Medical Sciences, Moscow Healthcare Department
Russian Federation, Moscow; MoscowDmitry O. Dragunov
Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical Management, Moscow Healthcare Department
Email: tamops2211@gmail.com
ORCID iD: 0000-0003-1059-8387
Cand.Sci. (Med.), Associate Professor at the Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine, Pirogov Russian National Research Medical University (Pirogov University); Head of the Organizational and Methodological Department for Therapy, Research Institute of Healthcare and Medical Sciences, Moscow Healthcare Department
Russian Federation, Moscow; MoscowGrigory P. Arutyunov
Pirogov Russian National Research Medical University
Email: arut@ossn.ru
ORCID iD: 0000-0002-6645-2515
Dr.Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine
Russian Federation, MoscowEkaterina V. Toporkova
Pirogov Russian National Research Medical University
Email: katemmiracle@yandex.ru
ORCID iD: 0009-0009-9152-1920
2nd-year Resident, Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine
Russian Federation, MoscowDzhamilya R. Suleymanova
Pirogov Russian National Research Medical University
Email: jamilyasr2003@mail.ru
ORCID iD: 0009-0009-0293-7394
1st-year Resident, Department of Propaedeutics of Internal Medicine No. 1, Institute of Clinical Medicine
Russian Federation, MoscowSabo R. Abdusalyamova
Pirogov Russian National Research Medical University
Email: sabo-02@mail.ru
ORCID iD: 0009-0005-5388-9848
6th year Student, Institute of Clinical Medicine
Russian Federation, MoscowDaria Igorevna Skripachuk
Pirogov Russian National Research Medical University
Email: dhvnldhvnl@gmail.com
ORCID iD: 0009-0006-8745-4989
6th year Student, Institute of Clinical Medicine
Russian Federation, MoscowReferences
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