Malignant neoplasms in the structure of mortality in kidney transplant recipients

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Abstract

Introduction. Kidney transplant recipients are at increased risk of malignant neoplasms compared to patients who have not undergone kidney transplantation, which is associated with the influence of specific factors inherent to this group.

Objective. To determine the role of malignant neoplasms in the structure of mortality in kidney transplant recipients.

Material and methods. The literature review was conducted using PubMed, Scopus, eLibrary, Web of Science, and Google Scholar databases. The search covered articles in Russian and English. From the initial selection of 69 publications, 28 of the most relevant studies from 2020 to 2025 were selected, corresponding to the objective of the review.

Conclusion. Kidney transplant recipients have increased incidence and mortality from malignant neoplasms compared to the general population. The high heterogeneity in cancer mortality rates among recipients across countries is likely due not only to regional differences in cancer incidence but also to the implementation of malignant neoplasm screening, which enables early detection of tumors.

About the authors

Ruslan N. Trushkin

State Budgetary Institution of Healthcare, Moscow Clinical Research Center, Hospital No. 52 of the Moscow Department of Healthcare; Patrice Lumumba Peoples' Friendship University of Russia

Author for correspondence.
Email: uro52@mail.ru
ORCID iD: 0000-0002-3108-0539

Professor, DSc, Head of the Urology Department State Budgetary Institution of Healthcare, Moscow Clinical Research Center, Hospital No.52 of the Moscow Department of Healthcare; Department of Urology and Operative Nephrology with a Course in Oncourology, Patrice Lumumba Peoples' Friendship University of Russia

Russian Federation, Moscow; Moscow

Teymur K. Isaev

State Budgetary Institution of Healthcare, Moscow Clinical Research Center, Hospital No. 52 of the Moscow Department of Healthcare

Email: dr.isaev@mail.ru
ORCID iD: 0000-0003-3462-8616

DSc, Urologist of the urology department

Russian Federation, Moscow

Aleksandr A. Sokolov

Federal State Budgetary Institution, Central Clinical Hospital with a Polyclinic of the Administrative Department of the President of the Russian Federation

Email: salexdoc@gmail.com
ORCID iD: 0009-0007-0302-0428

PhD, Urologist in the oncourology department

Russian Federation, Moscow

Sergey A. Sokolov

State Budgetary Institution of Healthcare, Moscow Clinical Research Center, Hospital No. 52 of the Moscow Department of Healthcare

Email: sergey.sokolow28@mail.ru
ORCID iD: 0009-0004-7016-2360

Urologist of the urology department

Russian Federation, Moscow

Vladimir E. Vinogradov

State Budgetary Institution of Healthcare, Moscow Clinical Research Center, Hospital No. 52 of the Moscow Department of Healthcare

Email: vino-gradoff@yandex.ru
ORCID iD: 0000-0002-0184-346X

Head of the Consultative and Diagnostic Nephrology Department

Russian Federation, Moscow

Isaeva Anastasia M.

Federal State Budgetary Institution, Central Clinical Hospital with a Polyclinic of the Administrative Department of the President of the Russian Federation

Email: antropik88@mail.ru
ORCID iD: 0009-0008-9362-4475

Gynecologist of gynecological department No. 2 Federal

Russian Federation, Moscow

Vasilisa R. Trushkina

Federal State Budgetary Educational Institution of Higher Education, Lomonosov Moscow State University

Email: vasilisa.trushkina.07@mail.ru

Student of the medical faculty

Russian Federation, Moscow

References

  1. Axelrod D.A., Schnitzler M.A., Xiao H. et al. An economic assessment of contemporary kid-ney transplant practice. Am. J. Transplant. 2018;18(5):1168–76. doi: 10.1111/ajt.14702.
  2. Готье С.В., Хомяков С.М. Донорство и трансплантация органов в Российской Федерации в 2023 г. XVI сообщение регистра Российского трансплантологического общества. Вестник трансплантологии и искусственных органов. 2024;26(3):8–31. [Gautier S.V., Khomyakov S.M. Organ donation and transplantation in the Russian Federation in 2023. 16th Report from the Registry of the Russian Transplant Society. Rus. J. Transplantol. Artificial Organs. 2024;26(3):8–31 (In Russ.)]. https:// doi.org/10.15825/1995-1191-2024-3-8-31.
  3. Benoni H., Eloranta S., Dahle D.O. et al. Relative and absolute cancer risks among Nordic kidney transplant recipients-a population-based study. Transpl. Int. 2020;33(12):1700–10. doi: 10.1111/tri.13734.
  4. Conlon E., Fitzgerald C., Hintze J. et al. High frequency and mortality of head and neck malignancy in organ transplant recipients in Ireland - A national cohort study. Am. J. Otolaryngol. 2023;44(4):103827. Doi: 10.1016/ j.amjoto.2023.103827.
  5. Blosser C.D., Haber G., Engels E.A. Changes in cancer incidence and outcomes among kidney transplant recipients in the United States over a thirty-year period. Kidney Int. 2021;99(6):1430–8. doi: 10.1016/j.kint.2020.10.018. [Epub 2020 Nov 5, PMID: 33159960, PMCID: PMC8096865].
  6. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2020. CA Cancer J. Clin. 2020;70(1):7–30. doi: 10.3322/caac.21590. [Epub 2020 Jan 8, PMID: 31912902].
  7. Porta C., Bamias A., Danesh F.R. et al. KDIGO Controversies Conference on onco-nephrology: understanding kidney impairment and solid-organ malignancies, and managing kidney cancer. Kidney Int. 2020;98(5):1108–19. doi: 10.1016/j.kint.2020.06.046. [PMID: 33126977].
  8. Sprangers B., Nair V., Launay-Vacher V. et al. Risk factors associated with post-kidney transplant malignancies: an article from the Cancer-Kidney International Network. Clin. Kidney J. 2018;11(3):315–29. doi: 10.1093/ckj/sfx122. [Epub 2017 Oct 27, PMID: 29942495, PMCID: PMC6007332].
  9. Taborelli M., Serraino D., Cimaglia C. et al. The impact of cancer on the risk of death with a functioning graft of Italian kidney transplant recipients. Am. J. Transplant. 2022;22(2):588–98. doi: 10.1111/ajt.16825. [Epub 2021 Sep 15, PMID: 34464503].
  10. Ying T., Shi B., Kelly P.J. et al. Death after Kidney Transplantation: An Analysis by Era and Time Post-Transplant. J. Am. Soc. Nephrol. 2020;31(12):2887–99. doi: 10.1681/ASN.2020050566. [Epub 2020 Sep 9, PMID: 32908001, PMCID: PMC7790214].
  11. Wang J.H., Pfeiffer R.M., Musgrove D. et al. Cancer Mortality Among Solid Organ Transplant Recipients in the United States During 1987–2018. Transplantation. 2023;107(11):2433–42. doi: 10.1097/TP.0000000000004694. [Epub 2023 Jun 9, PMID: 37291711, PMCID: PMC10615843].
  12. Acuna S.A., Fernandes K.A., Daly C. et al. Cancer Mortality Among Recipients of Solid-Organ Transplantation in Ontario, Canada. JAMA. Oncol. 2016;2(4):463–9. doi: 10.1001/jamaoncol.2015.5137. [PMID: 26746479].
  13. Wetering J., Roodnat J.I., Hemke A.C. et al. Patient survival after the diagnosis of cancer in renal transplant recipients: a nested case-control study. Transplantation. 2010;90(12):1542–6. doi: 10.1097/TP.0b013e3181ff1458. [PMID: 21076383].
  14. Mayrdorfer M., Liefeldt L., Osmanodja B. et al. A single centre in-depth analysis of death with a functioning kidney graft and reasons for overall graft failure. Nephrol. Dial. Transplant. 2023;38(8):1857–66. doi: 10.1093/ndt/gfac327. [PMID: 36477607, PMCID: PMC10387383].
  15. Taborelli M., Serraino D., Cimaglia C. et al. Cancer mortality after kidney transplantation: A multicenter cohort study in Italy. Int. J. Cancer. 2024;154(5):842–51. doi: 10.1002/ijc.34787. [Epub 2023 Nov 4, PMID: 37924271].
  16. Re Sartò G.V., Alfieri C., Cosmai L. et al. Post-Kidney Transplant Cancer: A Real-World Retrospective Analysis From a Single Italian Center. Transpl. Int. 2024;37:13220. doi: 10.3389/ti.2024.13220. [PMID: 39228659, PMCID: PMC11368674].
  17. Schreiber B., Abdelrahim M., Abudayyeh A., Murakami N. Emerging Concepts in Managing Malignancy in Kidney Transplant Patients. Semin. Nephrol. 2022;42(1):63–75. doi: 10.1016/j.semnephrol.2022.01.003. [PMID: 35618396, PMCID: PMC9139423].
  18. Krishnan A., Wong G., Teixeira-Pinto A., Lim W.H. Incidence and Outcomes of Early Cancers After Kidney Transplantation. Transpl. Int. 2022;35:10024. doi: 10.3389/ti.2022.10024. [PMID: 35592449, PMCID: PMC9110645].
  19. Rosales B.M., De La Mata N., Vajdic C.M., et al. Cancer mortality in kidney transplant recipients: An Australian and New Zealand population-based cohort study, 1980-2013. Int. J. Cancer. 2020;146(10):2703–11. doi: 10.1002/ijc.32585. [Epub 2019 Aug 23, PMID: 31340063].
  20. Farrugia D., Mahboob S., Cheshire J. et al. Malignancy-related mortality following kidney transplantation is common. Kidney Int. 2014;85(6):1395–403. doi: 10.1038/ki.2013.458. [Epub 2013 Nov 20, PMID: 24257690].
  21. Jiang F., Wang F., Zhang T. et al. Current Trends and Future Directions of Malignancy After kidney Transplantation: A 1970–2022 Bibliometric Analysis. Ann. Transplant. 2024;29:e942074. doi: 10.12659/AOT.942074. [PMID: 38163947, PMCID: PMC10771012].
  22. Laowalert S., Naitook N., Boonnim K. et al. Report on post-transplantation cancer in southeast Asia from the Thai kidney transplantation cohort. Sci. Rep. 2024;14(1):20154. doi: 10.1038/s41598-024-71041-x. [PMID: 39215076, PMCID: PMC11364626].
  23. Li S., Zhang J., Tian Y. et al. De novo upper tract urothelial carcinoma after renal transplantation: a single-center experience in China. BMC. Urol. 2023;23(1):23. doi: 10.1186/s12894-023-01190-0. [PMID: 36803451, PMCID: PMC9940364].
  24. Jeong S., Lee H.S., Kong S.G. et al. Incidence of malignancy and related mortality after kidney transplantation: a nationwide, population-based cohort study in Korea. Sci. Rep. 2020;10(1):21398. doi: 10.1038/s41598-020-78283-5. [PMID: 33293655, PMCID: PMC7722878].
  25. Cheung C.Y., Lam M.F., Chu K.H. et al. Malignancies after kidney transplantation: Hong Kong renal registry. Am. J. Transplant. 2012;12(11):3039–46. doi: 10.1111/j.1600-6143.2012.04209.x. [Epub 2012 Aug 6, PMID: 22883513].
  26. Minkovich M., Wong R.B.K., Famure O. et al. Renal cell carcinoma in kidney transplant recipients: incidence, trends, clinical management & outcomes. World J. Urol. 2023;41(9):2389–95. doi: 10.1007/s00345-023-04495-9. [Epub 2023 Jul 14, PMID: 37450008].
  27. McMichael L.C., Gulyani A., Clayton P.A. Assessing survival post-kidney transplantation in Australia: A multivariable prediction model. Nephrology (Carlton). 2024;29(3):143–53. doi: 10.1111/nep.14257. [Epub 2023 Nov 28, PMID: 38014653].
  28. Udomkarnjananun S., Townamchai N., Kerr S.J. et al. The First Asian Kidney Transplantation Prediction Models for Long-term Patient and Allograft Survival. Transplantation. 2020;104(5):1048–57. doi: 10.1097/TP.0000000000002918. [PMID: 31415034].

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