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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Clinical nephrology</journal-id><journal-title-group><journal-title xml:lang="en">Clinical nephrology</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая нефрология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-3594</issn><issn publication-format="electronic">2414-9322</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">245988</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">HCV-associated cryoglobulinemic vasculitis with severe kidney involvement and B-cell lymphoma development. Monoclonal anti-CD-20 antibodies and antiviral therapy as options of prognosis improvement</article-title><trans-title-group xml:lang="ru"><trans-title>HCV-ассоциированный криоглобулинемический васкулит с тяжелым поражением почек и развитием В-клеточной лимфомы. Современные возможности изменения прогноза с помощью моноклональных антител к CD20 и противовирусной терапии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mukhin</surname><given-names>N A</given-names></name><name xml:lang="ru"><surname>Мухин</surname><given-names>Н А</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, МоскваГУ НИИ ревматологии РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kozlovskaya</surname><given-names>L V</given-names></name><name xml:lang="ru"><surname>Козловская</surname><given-names>Л В</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, МоскваГУ НИИ ревматологии РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Milovanova</surname><given-names>L Yu</given-names></name><name xml:lang="ru"><surname>Милованова</surname><given-names>Л Ю</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, МоскваГУ НИИ ревматологии РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tegay</surname><given-names>S V</given-names></name><name xml:lang="ru"><surname>Тэгай</surname><given-names>С В</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, МоскваГУ НИИ ревматологии РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gordovskaya</surname><given-names>N B</given-names></name><name xml:lang="ru"><surname>Гордовская</surname><given-names>Н Б</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, МоскваГУ НИИ ревматологии РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ignatova</surname><given-names>T M</given-names></name><name xml:lang="ru"><surname>Игнатова</surname><given-names>Т М</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, МоскваГУ НИИ ревматологии РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kudlinskiy</surname><given-names>I S</given-names></name><name xml:lang="ru"><surname>Кудлинский</surname><given-names>И С</given-names></name></name-alternatives><bio xml:lang="ru"><p>ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, МоскваГУ НИИ ревматологии РАМН, Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ГОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития России, МоскваГУ НИИ ревматологии РАМН, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2011</year></pub-date><issue>2</issue><issue-title xml:lang="en">NO2 (2011)</issue-title><issue-title xml:lang="ru">№2 (2011)</issue-title><fpage>61</fpage><lpage>69</lpage><history><date date-type="received" iso-8601-date="2023-02-17"><day>17</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, ООО «Бионика Медиа»</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2075-3594/article/view/245988">https://journals.eco-vector.com/2075-3594/article/view/245988</self-uri><abstract xml:lang="en"><p>Clinical evolution of severe kidney damage, development of B-cell lymphoma, and advantages of antiviral therapy and rituximab are discussed</p></abstract><trans-abstract xml:lang="ru"><p>На примере конкретного пациента обсуждается поражение почек при HCV-ассоциированной криоглобулинемии, развитие В-клеточной лимфомы и современные возможности противовирусной терапии и лечения моноклональными антителами к CD20.</p></trans-abstract><kwd-group xml:lang="en"><kwd>: HCV-associated cryoglobulinemia</kwd><kwd>kidney involvement</kwd><kwd>B-cell lymphoma</kwd><kwd>antiviral therapy</kwd><kwd>rituximab</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>HCV-ассоциированная криоглобулинемия</kwd><kwd>поражение почек</kwd><kwd>В-клеточная лимфома</kwd><kwd>противовирусная терапия</kwd><kwd>ритуксимаб</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Игнатова Т.М., Апросина З.Г., Серов В.В., Мухин Н.А.. 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