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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Clinical nephrology</journal-id><journal-title-group><journal-title xml:lang="en">Clinical nephrology</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая нефрология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-3594</issn><issn publication-format="electronic">2414-9322</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">262632</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Nocturia as a topical interdisciplinary problem of integrative medicine in xxi century: epidemiology and association with age-related comorbidity</article-title><trans-title-group xml:lang="ru"><trans-title>Ноктурия как актуальная междисциплинарная проблема интегративной медицины XXI в.: эпидемиология и связь с возраст-ассоциированной коморбидностью</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tyuzikov</surname><given-names>I. A</given-names></name><name xml:lang="ru"><surname>Тюзиков</surname><given-names>И. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-уролог-андролог высшей категории, заслуженный работник науки и образования, к.м.н., профессор рае</p></bio><email>phoenix-67@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kalinchenko</surname><given-names>S. Yu</given-names></name><name xml:lang="ru"><surname>Калинченко</surname><given-names>С. Ю</given-names></name></name-alternatives><bio xml:lang="ru"><p>зав. кафедрой эндокринологии ФПК МР РУДН, д.м.н., профессор</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vorslov</surname><given-names>L. O</given-names></name><name xml:lang="ru"><surname>Ворслов</surname><given-names>Л. О</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра эндокринологии ФПК МР РУДН, к.м.н., профессор</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tishova</surname><given-names>Yu A.</given-names></name><name xml:lang="ru"><surname>Тишова</surname><given-names>ЮА. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра эндокринологии ФПК МР РУДН, к.м.н., доцент</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Grekov</surname><given-names>E. A</given-names></name><name xml:lang="ru"><surname>Греков</surname><given-names>Е. А</given-names></name></name-alternatives><bio xml:lang="ru"><p>зав. урологическим отделением</p></bio><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Российская академия естествознания</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="ru">Клиника «Гармония»</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="ru">РУДН</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff id="aff4"><institution>Клиника профессора Калинченко</institution></aff><pub-date date-type="pub" iso-8601-date="2014-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2014</year></pub-date><issue>5</issue><issue-title xml:lang="en">NO5 (2014)</issue-title><issue-title xml:lang="ru">№5 (2014)</issue-title><fpage>48</fpage><lpage>55</lpage><history><date date-type="received" iso-8601-date="2023-02-21"><day>21</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО «Бионика Медиа»</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2075-3594/article/view/262632">https://journals.eco-vector.com/2075-3594/article/view/262632</self-uri><abstract xml:lang="en"><p>In a review article discusses the epidemiological and medico-social aspects of the symptoms of night urination (nocturia), based on the results of modern evidence-based research in this area and our own clinical data. The results of all epidemiological studies show that nocturia is a universal aging phenomenon, gender devoid of color, not just the symptom of men with benign prostatic hyperplasia, as is often assumed so far. Its frequency in both men and women has been steadily progressing with age. Nocturia often occurs and progresses on the background of the majority of age-related diseases, and between them and nocturia there is a reliable two-way communication pathogenetic relation: the emergence of nocturia aggravates the clinical course of the existing of aging psychosomatic pathology and, conversely, any aging diseases can induce and contribute to the progression of nocturia. As a result, not only dramatically reduces the quality of life of older people, but also significantly reduced their survival against the background of an increased risk of death from any causes. This reflects the closed relationship of nocturia with other age-related diseases, is the essence of age and comorbid diseases makes the issue of nocturia one of the most urgent problems of modern integrative interdisciplinary clinical medicine.</p></abstract><trans-abstract xml:lang="ru"><p>В обзорной статье рассматриваются эпидемиологические и медико-социальные аспекты симптома ночного мочеиспускания (ноктурии), базирующиеся на результатах современных доказательных исследований в этой области и собственных клинических данных. Результаты всех эпидемиологических исследований показывают, что ноктурия является универсальным возрастным феноменом, лишенным гендерной окраски, а не только симптомом, характерным для мужчин с доброкачественной гиперплазией предстательной железы, как нередко принято считать до сих пор. Ее частота как у мужчин, так и у женщин неуклонно прогрессирует с возрастом. Ноктурия часто протекает и прогрессирует на фоне большинства возраст-ассоциированных заболеваний, между которыми и ноктурией существует достоверная двусторонняя патогенетическая связь: появление ноктурии усугубляет клиническое течение имеющейся возрастной психосоматической патологии, и наоборот, любые заболевания стареющего человека могут индуцировать и способствовать прогрессированию ноктурии. в итоге не только резко снижается качество жизни пожилых людей, но и существенно уменьшается их выживаемость на фоне роста повышенного риска летальных исходов от любых причин. Данный факт отражает тесную связь ноктурии с другими возраст-ассоциированными заболеваниями, составляющими суть возрастной коморбидной патологии, и делает ноктурию одной из самых актуальных междисциплинарных проблем современной интегративной клинической медицины.</p></trans-abstract><kwd-group xml:lang="en"><kwd>nocturia</kwd><kwd>epidemiology</kwd><kwd>comorbidity</kwd><kwd>age-related diseases</kwd><kwd>interdisciplinary interactions</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ноктурия</kwd><kwd>эпидемиология</kwd><kwd>коморбидность</kwd><kwd>возраст-ассоциированные заболевания</kwd><kwd>междисциплинарные взаимодействия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Лопаткин Н.А. Урология: учебник для медициснких вузов. - М. - 1982.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Van Kerrebroeck P., Abrams P., Chaikin D. 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