Clinical nephrologyClinical nephrologyКлиническая нефрология2075-35942414-9322Bionika Media67928810.18565/nephrology.2025.1.86-94Literature ReviewsОбзоры литературыReview ArticlePrevalence and pathogenesis of kidney damage in non-alcoholic fatty liver disease – possibilities of early diagnostics using fluorescence organoscopyРаспространенность и патогенез поражения почек при неалкогольной жировой болезни печени – возможности ранней диагностики с помощью флуоресцентной органоскопииhttps://orcid.org/0000-0001-6796-4064LelyavinaT. A.ЛелявинаТ. А.
Russian Federation

Dr.Sci. (Med.), Leading Researcher, Research Institute of Myocardial Microcirculation and Metabolism, Institute of Experimental Medicine

д.м.н., ведущий научный сотрудник НИО микроциркуляции и метаболизма миокарда Института экспериментальной медицины

tatianalelyavina@mail.ruGalagudzaM. M.ГалагудзаМ. М.
Russian Federation

Dr.Sci. (Med.), Professor and Corresponding Member of the Russian Academy of Sciences, Director of the Institute of Experimental Medicine

д.м.н., профессор и чл.-корр. РАН, директор института экспериментальной медицины

tatianalelyavina@mail.ruSoninD. L.СонинД. Л.
Russian Federation

Cand.Sci. (Med.), Head of Research Institute of Myocardial Microcirculation and Metabolism

к.м.н., заведующий НИО микроциркуляции и метаболизма миокарда

tatianalelyavina@mail.ruhttps://orcid.org/0000-0003-2767-7153PopovS. V.ПоповС. В.
Russian Federation

Dr.Sci. (Med.), professor, Chief, Head of the Center of Endourology and New Technologies

д.м.н., профессор; главный врач, руководитель городского центра эндоскопической урологии и новых технологий

doc.popov@gmail.comhttps://orcid.org/0000-0001-9935-0243GuseinovR. G.ГусейновР. Г.
Russian Federation

Cand.Sci. (Med.), Deputy Director on Scientific work, senior tutor of the Department of Surgery and Urology

к.м.н., заместитель главного врача по научной деятельности, старший преподаватель кафедры хирургии и урологии.

rusfa@yandex.ruBeshtoevA. Kh.БештоевА. Х.
Russian Federation

Researcher

научный сотрудник

akhmed.beshtoev@gmail.comhttps://orcid.org/0000-0001-6294-6182MalyshevE. A.МалышевЕ. А.
Russian Federation

Researcher

научный сотрудник

malyshevyegor@gmail.comAlmazov National Medical Research CenterФГБУ «НМИЦ им. В.А. Алмазова» Минздрава РФSaint Luke Clinical HospitalСПб ГБУЗ «Клиническая больница Святителя Луки»Saint Petersburg Medical and Social InstituteЧОУ ВО «Санкт-Петербургский медико-социальный институт»Saint Petersburg State UniversityФГБОУ ВО «Санкт-Петербургский государственный университет»1503202517186940805202508052025Copyright ©; 2025, Bionika MediaCopyright ©; 2025, ООО «Бионика Медиа»2025Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2075-3594/article/view/679288

Due to the increasing prevalence of obesity and diabetes worldwide, the overall incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) is expected to increase. Risk factors for NAFLD are associated with the development of chronic kidney disease (CKD). This article discusses the epidemiology, risk factors, genetics, and specific pathogenetic mechanisms linking NAFLD with CKD: ectopic lipid accumulation, cellular signaling disorders, the relationship between fructose consumption and uric acid accumulation, etc. The possibilities of early diagnosis of these pathological conditions using fluorescence organoscopy are discussed.

В связи с растущей распространенностью ожирения и диабета во всем мире ожидается рост общей заболеваемости и распространенности неалкогольной жировой болезни печени (НАЖБП). Факторы риска НАЖБП связаны с развитием хронической болезни почек (ХБП). В настоящей статье рассмотрены эпидемиология, факторы риска, генетика и специфические патогенетические механизмы, связывающие НАЖБП с ХБП: эктопическое накопление липидов, нарушения клеточной сигнализации, связь между потреблением фруктозы и накоплением мочевой кислоты и т.д. Обсуждены возможности ранней диагностики данных патологических состояний с помощью флуоресцентной органоскопии.

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