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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Clinical nephrology</journal-id><journal-title-group><journal-title xml:lang="en">Clinical nephrology</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническая нефрология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2075-3594</issn><issn publication-format="electronic">2414-9322</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">679946</article-id><article-id pub-id-type="doi">10.18565/nephrology.2024.4.45-47</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Clinical case</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Наблюдения из практики</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Multifactorial kidney damage in a comorbid patient</article-title><trans-title-group xml:lang="ru"><trans-title>Многофакторное поражение почек у коморбидной пациентки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4388-5609</contrib-id><name-alternatives><name xml:lang="en"><surname>Yumasheva</surname><given-names>Valentina A.</given-names></name><name xml:lang="ru"><surname>Юмашева</surname><given-names>Валентина Алексеевна</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><bio xml:lang="en"><p>6th-Year Student, Sechenov University</p></bio><bio xml:lang="ru"><p>студент VI курса</p></bio><email>valentina-jumasheva@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6425-0621</contrib-id><name-alternatives><name xml:lang="en"><surname>Komarova</surname><given-names>Irina S.</given-names></name><name xml:lang="ru"><surname>Комарова</surname><given-names>Ирина Севастьяновна</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><bio xml:lang="en"><p>Cand.Sci. (Med.), Associate Professor, Department of Hospital Therapy No. 2</p></bio><bio xml:lang="ru"><p>к.м.н., доцент кафедры госпитальной терапии № 2</p></bio><email>plaksuchka@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3329-7846</contrib-id><name-alternatives><name xml:lang="en"><surname>Rachina</surname><given-names>Svetlana A.</given-names></name><name xml:lang="ru"><surname>Рачина</surname><given-names>Светлана Александровна</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><bio xml:lang="en"><p>Dr.Sci. (Med.), Head of the Department of Hospital Therapy No. 2</p></bio><bio xml:lang="ru"><p>д.м.н., заведующая кафедрой госпитальной терапии № 2</p></bio><email>Stchina@avetlana.Rantibiotic.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5094-1261</contrib-id><name-alternatives><name xml:lang="en"><surname>Mayorov</surname><given-names>Vasily V.</given-names></name><name xml:lang="ru"><surname>Майоров</surname><given-names>Василий Владимирович</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><bio xml:lang="en"><p>Nephrologist</p></bio><bio xml:lang="ru"><p>врач-нефролог</p></bio><email>Vasso88-88@bk.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-3144-7165</contrib-id><name-alternatives><name xml:lang="en"><surname>Melnik</surname><given-names>Dmitry M.</given-names></name><name xml:lang="ru"><surname>Мельник</surname><given-names>Дмитрий Михайлович</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><bio xml:lang="en"><p>Nephrologist</p></bio><bio xml:lang="ru"><p>врач-нефролог</p></bio><email>melnik.nephro@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5807-5027</contrib-id><name-alternatives><name xml:lang="en"><surname>Mirzakhamidova</surname><given-names>Svetlana S.</given-names></name><name xml:lang="ru"><surname>Мирзахамидова</surname><given-names>Светлана Сергеевна</given-names></name></name-alternatives><address><country country="BY">Belarus</country></address><bio xml:lang="en"><p>Cand.Sci. (Med.), Deputy Chief Physician for Medical Work</p></bio><bio xml:lang="ru"><p>к.м.н., заместитель главного врача по лечебной работе</p></bio><email>rimatevs@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Sechenov University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">S.S. Yudin City Clinical Hospital</institution></aff><aff><institution xml:lang="ru">ГБУЗ «ГКБ им. С.С. Юдина»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-12-08" publication-format="electronic"><day>08</day><month>12</month><year>2024</year></pub-date><volume>16</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>45</fpage><lpage>47</lpage><history><date date-type="received" iso-8601-date="2025-05-19"><day>19</day><month>05</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-05-19"><day>19</day><month>05</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ООО «Бионика Медиа»</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2075-3594/article/view/679946">https://journals.eco-vector.com/2075-3594/article/view/679946</self-uri><abstract xml:lang="en"><p>Chronic kidney disease (CKD) is associated with severe comorbidity of a wide range of mental and physical conditions. The presence of concomitant pathologies aggravates the course of the underlying disease and contributes to the progression of kidney damage. The article presents a clinical description of a comorbid 80-year-old female patient with multifactorial renal damage due to arterial hypertension, viral hepatitis C, purine metabolism disorders, and markers of autoimmune damage based on the results of serological and intravital pathological examination. The mechanisms of complex renal damage and the importance of influencing them to maintain an optimal quality of life in a comorbid patient are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Хроническая болезнь почек (ХБП) связана с тяжелой коморбидностью широкого спектра психических и физических состояний. Наличие сопутствующих патологий отягощает течение основного заболевания и способствует прогрессированию поражения почек. Представлено клиническое описание коморбидной пациентки 80 лет с многофакторным поражением почек в результате гипертонической болезни, вирусного гепатита С, нарушения обмена пуринов, маркеров аутоиммунного поражения по результатам серологического и прижизненного патологоанатомического исследования. Обсуждаются механизмы комплексного поражения почек и важность воздействия на них для поддержания оптимального качества жизни коморбидной пациентки.</p></trans-abstract><kwd-group xml:lang="en"><kwd>comorbidity</kwd><kwd>renal damage</kwd><kwd>chronic kidney disease</kwd><kwd>nephrosclerosis</kwd><kwd>quality of life</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>коморбидность</kwd><kwd>поражение почек</kwd><kwd>хроническая болезнь почек</kwd><kwd>нефросклероз</kwd><kwd>качество жизни</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>MacRae C., Mercer S.W., Guthrie B., et al. Comorbidity in chronic kidney disease: a large cross-sectional study of prevalence in Scottish primary care. Br. J. Gen. Pract. 2021;71(704):243–9. Doi: 10.3399/bjgp20X714125.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>. Charles C., Ferris A.H. Chronic Kidney Disease. Prim. Care. 2020;47(4):585–95. Doi: 10.1016/j.pop.2020.08.001.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Ponticelli C., Doria A., Moroni G. Renal disorders in rheumatologic diseases: the spectrum is changing (Part 1: connective tissue diseases). J. Nephrol. 2021;34(4):1069–80. Doi: 10.1007/s40620-020-00772-7.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Kadowaki T., Maegawa H., Watada H., et al. Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan. Diab. Obes. Metab. 2022;24(12):2283–96. Doi: 10.1111/dom.14829.</mixed-citation></ref></ref-list></back></article>
