Clinical nephrologyClinical nephrologyКлиническая нефрология2075-35942414-9322Bionika Media69965710.18565/nephrology.2025.4.71-75Literature ReviewsОбзоры литературыReview ArticlePrinciples of treatment of malignant neoplasms in kidney transplant recipientsПринципы лечения злокачественных новообразований реципиентов почечного трансплантатаhttps://orcid.org/0000-0002-3108-0539TrushkinRuslan N.ТрушкинРуслан Николаевич
Russian Federation

Dr.Sci. (Med.), Head of the Urology Department

д.м.н., заведующий отделением урологии

uro52@mail.ruhttps://orcid.org/0009-0007-0302-0428SokolovAleksandr A.СоколовАлександр Александрович
Russian Federation

Cand.Sci. (Med.), Urologist

к.м.н., врач-уролог

salexdoc@gmail.comhttps://orcid.org/0009-0004-7016-2360SokolovSergey A.СоколовСергей Александрович
Russian Federation

Urologist, Urology Department

врач-уролог урологического отделения

sergey.sokolow28@mail.ruhttps://orcid.org/0000-0003-3462-8616IsaevTeymur K.ИсаевТеймур Карибович
Russian Federation

Dr.Sci. (Med.), Urologist, Urology Department

д.м.н., врач-уролог урологического отделения

dr.isaev@mail.ruIsaevaAnastasia M.ИсаеваАнастасия Михайловна
Russian Federation

Gynecologist

врач-гинеколог

antropik88@mail.ruMoscow Clinical Research Center, Hospital No. 52 of the Moscow Healthcare DepartmentГБУЗ «Московский клинический научно-исследовательский центр. Больница № 52» ДЗМCentral Clinical Hospital with Policlinic of the Administrative Directorate of the President of the Russian FederationФГБУ «Центральная клиническая больница с поликлиникой» УДП РФ27122025174717526122025Copyright ©; 2025, Bionika MediaCopyright ©; 2025, ООО «Бионика Медиа»2025Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2075-3594/article/view/699657

Treatment of malignant neoplasms in kidney transplant recipients has distinctive features compared to the non-transplant population. When a tumor is detected in recipients, immunosuppressive therapy is reduced or modified to enhance the natural immune system, followed by treatment. However, some medications that are standard in the non-transplant population are not used or are used only to a limited extent due to the increased risk of kidney graft rejection. The risk of graft rejection, difficulties in therapy, and small patient samples mean that some issues related to cancer treatment in kidney transplant recipients remain controversial and under study.

Лечение злокачественных новообразований у реципиентов почечного трансплантата имеет отличительные особенности по сравнению с нетрансплантированной популяцией. При выявлении опухоли у реципиентов для усиления естественного иммунитета проводится снижение или изменение режима иммуносупрессивной терапии, а далее – непосредственное лечение. При этом часть препаратов, являющихся стандартными в нетрансплантированной популяции, вследствие повышенных рисков отторжения трансплантированной почки не применяются или применяются ограниченно. Риски отторжения трансплантата, трудности при проведении терапии и малая выборка пациентов приводят к тому, что часть вопросов по лечению рака у реципиентов почечного трансплантата до сих пор остается дискутабельной и изучается.

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