Diaskintest® and Tigratest® TB: comparative characteristics and experience of application in the diagnostics of tuberculosis infection

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Abstract

Based on a review of domestic and international publications, this article compares the diagnostic capabilities of Diaskintest and IGRA tests for the detection of tuberculosis infection. It is demonstrated that Diaskintest® and IGRA tests are based on the detection of a cellular immune response to ESAT-6/CFP-10 antigens, ensuring their high specificity. The sensitivity of IGRA is 0.81–0.90, and the specificity is 0.95–0.99. Diaskintest® demonstrates comparable diagnostic efficacy with high specificity in BCG-vaccinated populations. The methods share a common antigen base but differ in the mechanism of immune response detection and are complementary.

About the authors

Olga O. Vinokurova

Peoples’ Friendship University of Russia

Author for correspondence.
Email: vinokurova-oo@rudn.ru
ORCID iD: 0000-0001-5689-7628

Cand. Med. Sci., Associate Professor, Department of Infectious Diseases with Courses in Epidemiology and Phthisiology

Russian Federation, Moscow

Marina V. Burakova

Peoples’ Friendship University of Russia

Email: burakova-mv@rudn.ru
ORCID iD: 0000-0003-0029-6297

Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases with Courses in Epidemiology and Phthisiology

Russian Federation, Moscow

Radmir M. Chotchayev

Peoples’ Friendship University of Russia

Email: chotchaev-rm@rudn.ru
ORCID iD: 0000-0001-9718-6005

MD, Professor, Department of Infectious Diseases with Courses in Epidemiology and Phthisiology

Russian Federation, Moscow

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