Epidemiology and Infectious Diseases. Current ItemsEpidemiology and Infectious Diseases. Current Items2226-69762414-9640Bionika Media28799410.18565/epidem.2022.12.4.61-7Research ArticleComparative analysis of specific and non-specific markers in patients with different stages of liver fibrosis in chronic hepatitis CNikolaevaLyudmila I.BD, leading researcher of laboratory of gene engineering productsl.i.nikolaeva@mail.ruShevchenkoNadezhda G.junior researcher of laboratory of gene engineering productsdr.nadya@inbox.ruDedovaAnna V.research assistant of laboratory of gene engineering productsdedova.anna2010@mail.ruSapronovGeorgiy V.PhD in medicine, senior researcher of laboratory of gene engineering productsg_sapronov@mail.ruSamokhvalovEvgeniy I.PhD in biology, leading researcher of laboratory ofviral ecologye-samokh@hotmail.comVakhromeevArtemiy A.junior researcher of laboratory of gene engineering productsbioartemiyvakhrameev@gmail.comHonorary Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of RussiaRussian Medical Academy of Continuing Professional Education, Ministry of Health15042022124616726022023Copyright © 2022, Bionika Media2022Objective. To study a possible relationship between individual stages of liver fibrosis (LF) in patients with chronic hepatitis C (CHC) and their virological, serological, and immunogenetic parameters. Subjects and methods. Five groups of150 patients were formed by the stage of LF. The latter was determined employing transient fibroelastometry. Hepatitis C virus (HCV) RNA was detected and quantified by reverse transcription PCR using 2 versions of the RealBest HCV RNA kit. Antibodies to HCV were detected in the RecombiBest anti-HCV IgM and RecombiBest anti-HCV spectrum test systems. Polymorphic loci of the IFNL3 (rs8099917 T/G) and IFNL4 (rs1297960 C/T) genes were genotyped using the IL28B Immunogenetics kit. Results. Comparison of the virological parameters did not reveal a significant relationship to a certain stage of LF. Among specific antibodies, only anti-HCV IgM showed an association with the fibrosis stages F2-F4 (p < 0.001). The detection rate for these antibodies significantly increased from F0 (46.7%) to F4 (93.3%). The ratio of genotype variants for polymorphic loci of the IFNL3 and IFNL4 genes changed with increasing LF stages. In the liver cirrhosis group, the CT-TG genotype was dominant, the differences in participants with F0 were significant (p = 0.0009). Conclusion. The prognostic markers of impending liver cirrhosis include anti-HCV IgM in high titers and the CT-TG genotype in the polymorphic loci of the IFNL4 (rs1297960 C/T) and IFNL3 (rs8099917 T/G) genes.chronic hepatitis Cfibrosisantibodiesgenetic polymorphismхронический гепатит Сфиброзантителагенетический полиморфизм[Daw M.A., El-Bouzedi A.A., Ahmed M.O., Dau A.A., Agnan M.M., Drah A.M. 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