Use of immunoglobulin against hepatitis B to prevent this infection
- Authors: Mukomolov S.L1, Mikhailov M.I2
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Affiliations:
- Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
- M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences
- Issue: No 1 (2014)
- Pages: 47-54
- Section: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/277352
- ID: 277352
Cite item
Abstract
For the specific prevention of hepatitis B (HB), it is advisable to use purified HB virus surface antigen (HBsAg)-based vaccines to form active immunity and HB immunoglobulin (HBIG) containing the high concentrations of antibodies to anti-HBsAg (anti-HBs). Active/passive immunization that contemplates the simultaneous administration of HBIG and HB vaccine is a preferred variant of emergency prevention of HB. This approach should be applied when there is a high probability of percutaneous HB virus inoculation after prick with a blood-contaminated needle or another sharp instrument; after bite or another skin injury; when there is a high risk of transmission across the mucosae, for example when infected blood gets on the conjunctiva and other mucosae; there is a risk of sexual transmission during unprotected heterosexual or homosexual contact; there is a high risk of transmission from the virus-carrying mother (who is ill with chronic HB) to her neonatal baby; for the prevention of recurrent HB after liver transplantation with or without specific antiviral drugs, as well as in those who are unresponsive to HB vaccination if there has been a likely contact with HB virus.
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About the authors
S. L Mukomolov
Saint Petersburg Pasteur Research Institute of Epidemiology and Microbiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
Email: s.mukomolov@mail.ru
M. I Mikhailov
M.P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russian Academy of Medical Sciences
Email: michmich2@yandex.ru
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