Two-drug antiretroviral therapy regimen with dolutegravir and lamivudine for previously untreated HIV-infected patients
- Authors: Koshkin A.M.1, Pokrovskaya A.V.2,3
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Affiliations:
- City Clinical Hospital
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- Peoples’ Friendship University of Russia
- Issue: Vol 13, No 3 (2023)
- Pages: 97-101
- Section: Reviews and Lectures
- URL: https://journals.eco-vector.com/2226-6976/article/view/625336
- DOI: https://doi.org/10.18565/epidem.2023.13.3.97–101
- ID: 625336
Cite item
Abstract
Combination triple antiretroviral therapy (ART) is the mainstay of treatment for people living with HIV (PLHIV). It allows patients to achieve viral load suppression and increase life expectancy to the general population level. However, these schemes in the long term can lead to the risk of developing adverse events from various organs and systems. The aging of the PLHIV population and the need to treat comorbidities lead to polypharmacy and an increased risk of drug interactions. For these reasons, two-drug ART regimens currently look promising. The article presents literature data on studies on the dual therapy of HIV infection. The combination dolutegravir + lamivudine is one of such regimen which has proven to be safe and effective in switching to it for previously treated patients. However, long-term safety and efficacy as a first-line regimen has not yet been adequately studied. Further research is required, including among people living with HIV in Russia.
Full Text
About the authors
Andrey M. Koshkin
City Clinical Hospital
Author for correspondence.
Email: andreykosh0@gmail.com
Infectious
Russian Federation, Zhukovsky, Moscow RegionAnastasia V. Pokrovskaya
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Peoples’ Friendship University of Russia
Email: pokrovskaya_av@mail.ru
ORCID iD: 0000-0002-2677-0404
MD, Senior Researcher, Associate Professor, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology
Russian Federation, Moscow; MoscowReferences
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