Current meningococcal vaccines and bacterial carriage
- Авторлар: Kostyukova N.N1, Bekhalo V.A1
-
Мекемелер:
- Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
- Шығарылым: Том 9, № 2 (2019)
- Беттер: 81-89
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/287340
- DOI: https://doi.org/10.18565/epidem.2019.9.2.81-9
- ID: 287340
Дәйексөз келтіру
Аннотация
The review presents information on the immunological and epidemiological efficacy of current meningococcal conjugate polysaccharide and protein (against serogroup B) vaccines. All literature sources indicate not only the high epidemiological efficacy of conjugate polysaccharide vaccines, but also their undoubted effects on the prevalence of carriage of the meningococcal serogroup homologous to the vaccine. Lower carriage is detected no earlier than several months after mass immunization. The protein vaccines against meningococcal serogroup B disease have high immunogenicity and epidemiological efficacy only if the composition of the vaccine is consistent with the protein antigens of the strain that causes the disease, mostly against porin A. In the insignificant number of studies so far, the direct effect of this vaccine on the prevalence of meningococcal serogroup B carriage could not be noted, but the groups are found to have a lower carriage of all meningococcal strains several months after immunization, which is explained by the cross-reactive antigens in the vaccine. Whether meningococcal carriage is completely eradicated under current conditions is discussed.
Толық мәтін
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Авторлар туралы
N. Kostyukova
Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
Email: nathakos@mail.ru
MD, Honored Scientist of the Russian Federation, Leading Researcher Moscow, Russia
V. Bekhalo
Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
Email: bekhalo@gamaleya.org
Cand. Biol. Sci., Leading Researcher Moscow, Russia
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