Anti-NMDA receptor encephalitis


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Аннотация

Absolutely healthy children of any age can spontaneously develop antibodies which bind to certain brain structures, the so-called N-methyl-D-aspartate (NMDA) receptors. The binding of these antibodies blocks the receptors and causes slowly progressive mental disorders, motor abnormalities, and seizures. The paper describes a clinical case of a disease in a 9-year-old female patient. The disease onset is marked by the manifestation of prodromal flu-like symptoms, fever, headache, and general weakness, followed by neuropsychiatric symptoms and impairments in memory and speech. Further progression of the disease caused convulsive status and later coma. The final diagnosis of autoimmune encephalitis was established after the complete blood count test identified anti-NMDA receptor antibodies.

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Рұқсат жабық

Авторлар туралы

Lala Ulukhanova

Dagestan State Medical University, Ministry of Health of Russia

Email: lala.uluhanova@mail.ru
MD, Head, Department of Propaedeutics of Children’s Diseases with a Course of Children’s Infections Makhachkala, Russia

Magomedzagir Yaraliev

S.M. Magomedov Dagestan Republican Center for Infectious Diseases, Prevention and Control of AIDS

Email: zagir0668@mail.ru
Head, Resuscitation Department Makhachkala, Russia

Nargiz Karnaeva

Dagestan State Medical University, Ministry of Health of Russia

Email: karnaeva79@mail.ru
Cand. Med. Sci., Assistant Lecturer, Department of Propaedeutics of Childhood Diseases with Course of Childhood Infections Makhachkala, Russia

Әдебиет тізімі

  1. Chapman M.R., Vause H.E. Anti-NMDA Receptor encephalitis: diagnosis, psychiatric presentation, and treatment. J. Psychiat 2011; 168(3): 245-51. Am. J. Psychiatr. 2011; 168(3): 245-51. DOI: 10.1176/ ppi. ajp.2010.10020181.
  2. Florance N.R. Anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents. Ann. Neurol. 2010; http://www.ncbi.nlm.nih. gov/pmc/articles/PMC2826225
  3. Iizuka T., Sakai F., Ide T., Monzen T., Yoshii S., Iigaya M., Suzuki K., Lynch D.R., Suzuki N., Hata T., Dalmau J. (February 2008). Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal. Neurology 2008; 70 (7): 504-11. doi: 10.1212/01.wnl. 0000278388.90370. c3. PMID: 17898324.
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  5. Florance N.R., Davis R.L., Lam C., Szperka C., Zhou L., Ahmad S., Campen C.J., Moss H., Peter N., Gleichman A.J., Glaser C.A., Lynch D.R., Rosenfeld M.R., Dalmau J. Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann. Neurol. 2009; 66(1): 11-8. doi: 10.1002/ana.21756. PMID: 19670433.
  6. Sansing L.H., Tüzün E., Ko M.W., Baccon J., Lynch D.R., Dalmau J. (May 2007). A patient with encephalitis associated with NMDA receptor antibodies. Nat. Clin. Pract. Neurol. 2007; 3(5): 291-6. DOI:10.1038/ ncpneuro0493. PMID: 17479076.

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