The course of acute hepatitis A in the presence of Helicobacter pylori infection


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Аннотация

Objective. To determine the impact of Helicobacter pylori infection on the course of acute hepatitis A (AHA). Subjects and methods. The investigation enrolled 69 patients (39 males and 30 females aged 16 to 55 years; their mean age was 30.3 ± 10.8 years) with mild and moderate AHA. In addition to the standard examination, all the patients underwent fibroesophagogastroduodenoscopy, by taking biosamples for cytology and determination of H. pylori infection rates. Results. In the examined patients, H. pylori was detected with a high frequency. Moreover, the presence of infection was associated with the degree of cytolysis by AsAT and AlAT and with the delayed normalization of bilirubin levels. The most significant hepatic dysfunctions were typical for patients with obvious H. pylori contamination in the gastric antral mucosa. Conclusion. The findings are consistent with the idea that there may be various variants of clinical and endoscopic (morphological) manifestations of H. pylori infection.

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Авторлар туралы

E. Karaseva

Acad. I.P. Pavlov Ryazan State Medical University, Ministry of Health of Russia

Email: ekar83@gmail.com

V. Martynov

Acad. I.P. Pavlov Ryazan State Medical University, Ministry of Health of Russia

Email: dr.Martynov@mail.ru

I. Klochkov

Acad. I.P. Pavlov Ryazan State Medical University, Ministry of Health of Russia

Email: doctor-endo@mail.ru

K. Ageeva

Acad. I.P. Pavlov Ryazan State Medical University, Ministry of Health of Russia

Email: inf-disease@mail.ru

L. Zhdanovich

Acad. I.P. Pavlov Ryazan State Medical University, Ministry of Health of Russia

Email: pyatovaluda@mail.ru

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