Self-sampling of biological material at the first stage of screening for HPV-associated diseases in HIV-infected women in the Moscow Region
- Авторлар: Popova A.A.1, Vinogradova N.А.1, Romanyuk T.N.1, Domonova E.A.1
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Мекемелер:
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- Шығарылым: Том 13, № 3 (2023)
- Беттер: 81-87
- Бөлім: Original Investigations
- URL: https://journals.eco-vector.com/2226-6976/article/view/625349
- DOI: https://doi.org/10.18565/epidem.2023.13.3.81–7
- ID: 625349
Дәйексөз келтіру
Аннотация
Objective. Evaluation of the effectiveness of using an individual set of consumables for self-collection of vaginal mucosa during testing for the detection of human papillomavirus (HPV) at the first stage of screening for cervical and vaginal precancerous diseases in HIV-infected women in the Moscow Region.
Materials and methods. The study involved 100 HIV-infected women. The results of testing of samples of vaginal mucosa, taken by the patient herself, and scraping of the cervical canal, taken by a gynecologist, were analyzed. The ease of use of the set of consumables was assessed using a questionnaire. Real-time PCR was used to determine HPV DNA. Cytological examination was performed using the technique of liquid cytology with Papanicolaou staining of cervical micropreparations.
Results. The frequency of detection of 13 high-risk oncogenic HPV types in samples of vaginal discharge and scraping of epithelial cells from the mucous membrane of the cervical canal was 42 and 30% (p > 0.05). According to the results of the survey (assessment was carried out on a 10-point scale, where difficult/very uncomfortable = 0, easy/very comfortable = 10), the ease of taking biological material was rated by study participants at an average of 9.4 points, the availability of understanding and ease of following the instructions – at 9.5 points, comfort of using the set – 8.9 points. An assessment of personal preferences in choosing a method for taking a biomaterial showed that only 15% of respondents would prefer a traditional visit to a gynecologist in the future.
Conclusion. There was no significant difference between the compared methods of taking biological material at the first stage of screening for cervical and vaginal precancerous diseases (p > 0.05). The use of an individual set of consumables for HPV testing will significantly increase the coverage of the population of HIV-infected women, as well as identify a risk group among them.
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Авторлар туралы
Anna Popova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Хат алмасуға жауапты Автор.
Email: asya-med@mail.ru
ORCID iD: 0000-0001-9484-5917
Cand. Med. Sci., Senior Researcher
Ресей, MoscowNadezhda Vinogradova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: klimova@cmd.su
ORCID iD: 0000-0003-3288-0244
Junior Researcher
Ресей, MoscowTatyana Romanyuk
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: tatiana.romaniuk@pcr.ms
ORCID iD: 0009-0006-1952-907X
Biologist
Ресей, MoscowElvira Domonova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: elvira.domonova@pcr.ms
ORCID iD: 0000-0001-8262-3938
Cand. Boil. Sci., Head, Research Group for the Development of New Methods for Diagnosing Opportunistic аnd Papillomavirus Infections, Department of Molecular Diagnostics and Epidemiology
Ресей, MoscowӘдебиет тізімі
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