Results of multi-year monitoring of the safety of immunization against rotavirus infection
- Авторлар: Shapovalova R.F.1, Mikheeva I.V.1, Mikheeva M.A.1, Аkimkin V.G.1
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Мекемелер:
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- Шығарылым: Том 14, № 2 (2024)
- Беттер: 6-12
- Бөлім: Epidemic Situation
- URL: https://journals.eco-vector.com/2226-6976/article/view/635088
- DOI: https://doi.org/10.18565/epidem.2024.14.2.6–12
- ID: 635088
Дәйексөз келтіру
Аннотация
Objective. Assessment of the safety of long-term vaccination of children with a live pentavalent recombinant rotavirus vaccine as part of a pilot project in Podolsk, Moscow region.
Materials and methods. A retrospective analysis of the incidence of intussusception (ICD-10 K56.1) was carried out based on data on hospitalization of children in a city hospital before (2013–2015) and against the background (2016–2022) of vaccinations against rotavirus infection (RVI). The data of expedited reports (form No 058u) and form No 2 of federal statistical observation, as well as reports of investigations of post-vaccination complications received by Territorial Administration of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being in the Moscow region in 2013–2022 were also studied.
Results. Over the 7 years, children received 38 144 vaccinations against RVI. No post-vaccination complications were recorded. The background incidence rate of intussusception in the city has not changed since the beginning of the pilot project. Over 10 years, 21 children were diagnosed with intussusception, four of them were vaccinated against RVI: two received the full course of vaccinations, two received only two vaccinations. The duration of the disease ranged from 69 days to 5 years after receiving the last dose of the vaccine, which indicated the absence of a cause-and-effect relationship between the cases of intussusception and the introduction of the rotavirus vaccine.
Conclusion. The results confirmed the published data on the safety of the pentavalent rotavirus vaccine. When organizing vaccine prevention of RVI, it is necessary to monitor adverse events in accordance with current guidelines.
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Авторлар туралы
Regina Shapovalova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Хат алмасуға жауапты Автор.
Email: Serena_13@mail.ru
ORCID iD: 0000-0003-0051-1866
Junior Researcher, Laboratory of Immunoprophylaxis
Ресей, MoscowIrina Mikheeva
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: Irina_Mikheeva@mail.ru
ORCID iD: 0000-0001-8736-4007
Professor, MD, Head, Laboratory of Immunoprophylaxis
Ресей, MoscowMarina Mikheeva
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: mikheeva.m@cmd.su
ORCID iD: 0000-0003-0290-388X
Junior Researcher, Laboratory of Immunoprophylaxis
Ресей, MoscowVasily Аkimkin
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: vgakimkin@yandex.ru
ORCID iD: 0000-0001-8139-0247
Professor, Academician of the Russian Academy of Sciences, МD, Director
Ресей, MoscowӘдебиет тізімі
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