Results of multi-year monitoring of the safety of immunization against rotavirus infection

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. Assessment of the safety of long-term vaccination of children with a live pentavalent recombinant rotavirus vaccine as part of a pilot project in Podolsk, Moscow region.

Materials and methods. A retrospective analysis of the incidence of intussusception (ICD-10 K56.1) was carried out based on data on hospitalization of children in a city hospital before (2013–2015) and against the background (2016–2022) of vaccinations against rotavirus infection (RVI). The data of expedited reports (form No 058u) and form No 2 of federal statistical observation, as well as reports of investigations of post-vaccination complications received by Territorial Administration of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being in the Moscow region in 2013–2022 were also studied.

Results. Over the 7 years, children received 38 144 vaccinations against RVI. No post-vaccination complications were recorded. The background incidence rate of intussusception in the city has not changed since the beginning of the pilot project. Over 10 years, 21 children were diagnosed with intussusception, four of them were vaccinated against RVI: two received the full course of vaccinations, two received only two vaccinations. The duration of the disease ranged from 69 days to 5 years after receiving the last dose of the vaccine, which indicated the absence of a cause-and-effect relationship between the cases of intussusception and the introduction of the rotavirus vaccine.

Conclusion. The results confirmed the published data on the safety of the pentavalent rotavirus vaccine. When organizing vaccine prevention of RVI, it is necessary to monitor adverse events in accordance with current guidelines.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Regina Shapovalova

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Хат алмасуға жауапты Автор.
Email: Serena_13@mail.ru
ORCID iD: 0000-0003-0051-1866

Junior Researcher, Laboratory of Immunoprophylaxis

Ресей, Moscow

Irina Mikheeva

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: Irina_Mikheeva@mail.ru
ORCID iD: 0000-0001-8736-4007

Professor, MD, Head, Laboratory of Immunoprophylaxis

Ресей, Moscow

Marina Mikheeva

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: mikheeva.m@cmd.su
ORCID iD: 0000-0003-0290-388X

Junior Researcher, Laboratory of Immunoprophylaxis

Ресей, Moscow

Vasily Аkimkin

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: vgakimkin@yandex.ru
ORCID iD: 0000-0001-8139-0247

Professor, Academician of the Russian Academy of Sciences, МD, Director

Ресей, Moscow

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Әрекет
1. JATS XML
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2. Fig. 1. Dynamics of vaccination coverage against RVI of children born in 2014-2022

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3. Fig. 2. Dynamics of incidence of intussusception in children under 6 years of age in Podolsk

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4. Fig. 3. Algorithm for assessing the cause and effect relationship of intussusceptions cases with the introduction of rotavirus vaccine

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