Participation of iron in the formation of nutritional immunity in patients with tick-borne rickettsiosis in the South of the Khabarovsk Krai

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Objective. Determination of the relationship between iron (Fe) levels and cytokine status in patients with tick-borne rickettsiosis (TBR) caused by R. heilongjiangensis in the dynamics of the disease for a better understanding of the pathogenesis of this pathology.

Materials and methods. The serum Fe and some proinflammatory cytokines (IL-6, IL-8, TNF-α) levels were analyzed in patients with moderate TBR taking into account a two-time examination: during hospitalization (at the height of the disease (4-5 days of illness)) and in the early convalescence period (8–10 days from the onset of the disease).

Results. It was found that at the height of the disease, a statistically significant decrease in the serum Fe level (by 4.7 times) was observed, which was combined with a reliably expressed activation of the endogenous mediators studied (IL-6 – by 56.1 times, IL-8 – by 4.8 times, TNF-α – by 9.5 times). However, already in the early convalescence period, against the background of a further decrease in the serum Fe concentration (by 5.6 times), the level of the studied interleukins significantly decreased (IL-6 and TNF-α by 7 and 2.6 times, respectively), remaining higher relative to the comparison group. When conducting a correlation analysis, a moderate unidirectional relationship between the level of Fe and the cytokine IL-6 was found.

Conclusion. The results obtained indicate an inductive effect of cytokine status elements on the unbound Fe level. IL-6, apparently, is a necessary cytokine for iron inhibition during inflammation and is involved in the development of protective hypoferremia in the formation of nutritional immunity in patients with TBR caused by R. heilongjiangensis.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Evgenia Mokretsova

Far Eastern State Medical University

Хат алмасуға жауапты Автор.
Email: bremer68@mail.ru
ORCID iD: 0000-0001-9492-2660

Cand. Med. Sci., Associate Professor at the Department of Infectious Diseases and Epidemiology

Ресей, Khabarovsk

Gennady Tomilka

Far Eastern State Medical University

Email: genntom@mail.fesmu.ru
ORCID iD: 0000-0002-8785-2147

MD, Professor, Head of the Department of Infectious Diseases and Epidemiology

Ресей, Khabarovsk

Alexander Shchupak

Far Eastern State Medical University

Email: schupakalex@mail.ru
ORCID iD: 0000-0001-6255-7638

Cand. Med. Sci., Associate Professor, Head of the Department of Clinical Toxicology and Extreme Medicine

Ресей, Khabarovsk

Yuri Kovalsky

Far Eastern State Medical University

Email: kovalyura@mail.ru
ORCID iD: 0000-0001-7433-6285

MD, Head of the Department of Biological Chemistry and Clinical Laboratory Diagnostics

Ресей, Khabarovsk

Victor Maleev

Central Research Institute of Epidemiology

Email: maleyev@pcr.ru
ORCID iD: 0000-0001-5748-178X

Academician of the Russian Academy of Sciences, MD, Professor, Advisor to the Director for Scientific Work

Ресей, Moscow

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