THREE SOURCES AND THREE COMPONENTS OF THE CONCEPT OF THE PATHOGENESIS OF INFECTIOUS DISEASE

The basis for the concept of the pathogenesis of infectious disease is the theory of the portal of entry of infection, a tropic organ, and variability. The course of disease and immediate and long-term outcomes are determined by the portal of entry through inoculation. If infection occurs naturally through the oropharynx, airways, gastrointestinal tract or skin, there is an adequate immune response and the disease manifests as typical clinical symptoms, shows a cyclic pattern, and usually results in recovery to confer complete sterile immunity. If the pathogen enters hematogenously (parenterally), including perinatally, there is no portal of entry so no adequate immune response forms and the disease has a chronic course involving the viscera due to the actuation of a mechanism of affinity evolution and to the emergence of new tropicity substrates in other organs. Full sanogenesis requires that the germ or its mediators should be present in the primary focus of infection. It is suggested, that HIV, HCV, hepatitis B virus, tetanus, rabies and other infections involving the viscera, as well as all slow infections should be interpreted as hematogenous infectious diseases that run due to the affinity evolution mechanism that gives rise to new tropicity substrates in the viscera. The theory of the portal of entry, tropicity, and the emergence of tropical substrates in the visceral organs should form the basis for modern infectology.

portal of entry of infection, tropic organ, affinity evolution as a key factor in the pathogenesis of chronic infection