PHARMACOECONOMICAL ANALYSIS OF ANTIRETROVIRAL THERAPY IN PATIENTS WITH HIV AND HEPATITIS B VIRUS CO-INFECTION
- Autores: KOZHEVNIKOVA G.M.1, EFREMOVA O.S2, JALLOLU A.1
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Afiliações:
- Peoples' Friendship University of Russia
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
- Edição: Nº 2 (2015)
- Páginas: 52-57
- Seção: Articles
- URL: https://journals.eco-vector.com/2226-6976/article/view/278220
- ID: 278220
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Resumo
Among HIV-positive patients, there are 10-15% cases of chronic hepatitis B virus (HBV) co-infection. This necessitates the choice of an optimal therapy regimen for both infections. Objective. To study the cost-effectiveness of drugs recommended for first-line antiretroviral therapy (ART) in HIV/HBV co-infected patients previously untreated with a fixed-dose combination (FDC) of TDF/FTC versus that of ABC/3TC and AZT/3TC. Subjects and methods. The pharmacoeconomical study was conducted using the simulation method to calculate direct medical costs. The model used the results of a study by L.M. Pawlotsky et al. reporting rates of HBV resistance to 3TC and TDF in a five-year time horizon. The risk of 3TC resistance progressively increases over time by achieving 70% at year 5 of treatment while that TDF resistance remains at zero throughout the therapy period. Results. The calculations in the model have indicated that the use of 3TC-containing FDCs in the five-year time horizon costs 53 400 rubles (or 7%) more than the baseline administration of TDF/FTC because of the development of HBV resistance and of the need for additional use of entecavir. Conclusion. The use of a FDC of TDF/FTC for first-line ART in previously untreated patients is economically sound in treating HIV/HBV co-infected patients in Russian clinical practice.
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Sobre autores
Galina KOZHEVNIKOVA
Peoples' Friendship University of Russia
Email: gmk10@mail.ru
Moscow
O. EFREMOVA
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Email: ks517@yandex.ru
Moscow
ABDURAHMAN. JALLOLU
Peoples' Friendship University of Russia
Email: gmk10@mail.ru
Moscow
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