Evaluation of the safety of children’s vaccination with combined preparations containing whole-cell or acellular pertussis vaccine

The paper comparatively analyzes the frequency and clinical manifestations of adverse events after injection of combined vaccines containing whole-cell (DTwP) or acellular (Infanrix, Pentaxim) pertussis components. The incidence of the adverse events after administration of the combined vaccines with a whole cell or acellular pertussis component is not found to differ (DTwP (0.8%), Infanrix (0.6%), Pentaxim (0.4%)). Short-term moderate health problems developed after injection of the vaccines in most (80 -98%) cases. Administration of the whole-cell vaccine significantly more frequently caused serious undesirable events from vaccination as a local abscess (21 cases), suggesting the higher safety profile of preparations containing an acellular pertussis component. By considering the complex vaccination schedule for children of the first year of life in the national immunization calendar of the Russian Federation, Pentaxim is the vaccine of choice in reducing an injection load.

children, vaccination, adverse events, whole-cell pertussis vaccine, acellular pertussis vaccine, multicomponent vaccine with an acellular pertussis component