Lung and liver changes during COVID-19 infection in the presence of liver cirrhosis


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Resumo

Patients with severe fibrosis and cirrhosis of the liver are a vulnerable group that is at an increased risk for infection with COVID-19 and hads its severe course due to the development of a systemic immunodeficiency state. The paper describes a case of severe COVID-19 infection associated with liver cirrhosis (Child-Pugh class B) in a 52-year-old female patient with a fatal outcome. The main causes of death were respiratory complications, as well as sudden deterioration in liver function, which led to end-stage disease.

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Sobre autores

Olga Vorobyeva

I.N. Ulyanov Chuvash State University

Email: olavorobeva@mail.ru
Cand. Med. Sci., Associate Professor, Department of General and Clinical Morphology and Forensic Medicine Cheboksary, Russia

Aleksey Lastochkin

I.N. Ulyanov Chuvash State University; Republican Bureau of Forensic Medicine

Email: alllex.08@mail.ru
Highest-Category Pathologist Cheboksary, Russia; Cheboksary, Russia

Natalia Gimaldinova

I.N. Ulyanov Chuvash State University

Email: rufer06@rambler.ru
Cand. Med. Sci., Associate Professor, Department of General and Clinical Morphology and Forensic Medicine Cheboksary, Russia

Lyubov Romanova

I.N. Ulyanov Chuvash State University

Email: samung2008@yandex.ru
Associate Professor, Department of Dermatovenereology with Course of Hygiene Cheboksary, Russia

Aleksandr Yusov

I.N. Ulyanov Chuvash State University

Email: yusov1961@yandexl.ru
Associate Professor, Department of Normal and Pathological Physiology Cheboksary, Russia

Bibliografia

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  2. Воробьева О.В., Ласточкин А.В. Патоморфологические изменения в органах при COVID-19. Инфекция и иммунитет 2020; 10(3): 587-90. https://doi.org/10.15789/2220-7619-PCI-1483
  3. Chai X., Hu L., Zhang Y., Han W., Lu Z., Ke A. et al. Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection. bioRxiv. doi: 10.1101/2020.02.03.931766
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  6. Li L., Li S., Xu M., Yu P., Zheng S., Dua Z. et al. Risk factors related to hepatic injury in patients with corona virus disease 2019. medRxiv 2020. doi: https://doi.org/10.1101/2020.02.28.20028514.
  7. Moon A.J. et al. High mortality rate for SARS-CoV2 infection in patients with pre-existing chronic liver disease and cirrhosis: preliminary results from an international registry. J. Hepatol. (advance online publication), 22 May 2020. https://doi.org/10.1016/johep.2020.05.013
  8. Sun J., Aghemo A., Forner A., Valenti L. COVID-19 and liver disease. Liver Int. 2020; 40(6): 1278-81. https://doi.org/10.1111/liv.14470

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