A CHANGE IN THE INDICATORS OF INTOXICATION SYNDROME IN HERPES INFECTION

Objective. To study a role of infective endotoxicosis in the pathogenesis of recurrent herpes infection, by determining the level of malondialdehyde and the proinflammatory cytokine tumor necrosis factor-a in relation to its stage, severity, and comorbidity. Subjects and methods. Eighty-nine patients with recurrent herpes infection were followed up. The blood levels of malondialdehyde and tumor necrosis factor-a were determined during the height of the disease, alleviation of clinical symptoms, early and, in some patients, late convalescence. Results. These indicators were found to be higher in relation to the period of the disease, its severity, and comorbidity. Conclusion. The found changes characterize the development of intoxication syndrome in herpes infection and may be used to evaluate disease severity and recovery completeness.

intoxication syndrome, herpes infection, malondialdehyde, tumor necrosis factor-a