INTERFERON-FREE ANTIVIRAL THERAPY FOR CHRONIC HEPATITIS C


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Antiviral therapy for chronic hepatitis C (CHC) is undergoing revolutionary changes: standard dual therapy is being gradually substituted by the triple therapy regimens containing the direct-acting antivirals (DAAs), pegylated interferons and ribavirin. The safety and tolerability of dual and triple therapies are comparable. Novel DAAs combinations make possible to achieve a sustained virologic response in 90-100% of patients with CHC in shorter periods have been designed in recent years. Moreover, interferon-free antiviral regimens have a good safety profile, which allows their use in patients with cirrhosis and in those who have contraindications to interferon-containing therapy. The review presents the characteristics of the main classes of DAAs and the results of completed clinical trials of interferon-free regimens.

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作者简介

Olga SAGALOVA

South ural State Medical university Clinic, Ministry of Health of Russia

Email: olga_sagalova@mail.ru
Chelyabinsk

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