Clinical features of leptospirosis in the Yaroslavl Region

Objective. To investigate the clinical features of leptospirosis in the people of the Yaroslavl Region. Materials and methods. Based on 120 inpatient health records, the authors retrospectively analyzed the clinical parameters of patients with leptospirosis who were treated at the Yaroslavl Infectious Diseases Clinical Hospital in 1985-2019. Results. Most (76.7%) cases had predominantly moderate leptospirosis. At the same time, its anicteric forms characterized by the clinical presentations typical of this infection were more common (79.3%). Its severe course was recorded less frequently (23.3% of cases), mainly in an icteric form (78.6%). Etiologically severe icteric forms were caused by leptospires from the Sejroe serogroup in every two patients. Patients with severe leptospirosis compared to those with its moderate severe form had myalgias less often (46.4% of cases) and lesions of the gastrointestinal tract more often. Complications mainly as acute renal and hepatorenal failure developed in 78.6% of patients. Conclusion. The identified regional clinical features of leptospirosis in the residents of the Yaroslavl Region are of fundamental importance for the timely diagnosis of the disease and the treatment of patients.

leptospirosis, Yaroslavl Region, clinical manifestations, myalgias, oliguria, laboratory parameters