Relationship between immunological parameters and the severity of liver fibrosis in patients with chronic hepatitis C
- 作者: Ponezheva Z.B.1, Akimkin V.G.1, Mannanova I.V.1, Ugleva S.V.1, Duganova S.E.2, Shabalina S.V.1
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隶属关系:
- Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
- Clinical Infectious Diseases Hospital Two
- 期: 卷 13, 编号 1 (2023)
- 页面: 78-82
- 栏目: Original Investigations
- URL: https://journals.eco-vector.com/2226-6976/article/view/321939
- DOI: https://doi.org/10.18565/epidem.2023.13.1.78–82
- ID: 321939
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Objective. To identify the relationship between immunological parameters and the severity of liver fibrosis (LF) in patients with chronic hepatitis C (CHC).
Subjects and methods. Examinations were made in 69 men and 48 women (mean age 45.7 ± 2.1 years) with a confirmed diagnosis of CHC. The number and functional activity of T lymphocyte subpopulations were studied by flow cytofluorometry using an EPICS XL cytometer (Beckman Coulter, USA). The serum concentration of interferons (IFN-α, IFN-γ, and IFN-λ) was estimated by an enzyme-linked immunosorbent assay (ELISA). Liver fibroelastometry was performed using a Fibroscan 502 device (Echosens, France), whereas the stage of fibrosis was determined using the METAVIR scoring system.
Results. An increase in the total number of T lymphocytes and T helper cells was detected in patients with CHC at all stages of LF. A significant decrease was found in B lymphocytes in patients with fibrosis stages F3 and F4. There was a tendency of IFN-α to decrease and IFN-λ to increase with progression of fibrosis stage.
Conclusion. The findings not only confirm the opinion about the pronounced immunosuppressive effect of viral hepatitis C, but also emphasize the importance of T cell immunity and IFN-γ in the prognosis of severe LF.
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作者简介
Zhanna Ponezheva
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
编辑信件的主要联系方式.
Email: doktorim@mail.ru
ORCID iD: 0000-0002-6539-4878
MD, Head, Clinical Infectious Pathology Department
俄罗斯联邦, MoscowVasily Akimkin
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: vgakimkin@yandex.ru
ORCID iD: 0000-0003-4228-9044
MD, Professor, Academician of the Russian Academy of Sciences, Director
俄罗斯联邦, MoscowIrina Mannanova
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: irinasemenova07@rambler.ru
Can. Med. Sci., Researcher, Clinical Infectious Pathology Department
俄罗斯联邦, MoscowSvetlana Ugleva
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: uglevasv@rambler.ru
ORCID iD: 0000-0002-1322-0155
MD, Associate Professor, Advisor, Organization and Guidance Department, Administrative Subdivision
俄罗斯联邦, MoscowSvetlana Duganova
Clinical Infectious Diseases Hospital Two
Email: Svetlana-msk@rambler.ru
MD, Infectiologist, Department Four
俄罗斯联邦, MoscowSvetlana Shabalina
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Email: svs2810@pcr.ru
MD, Professor, Leading Researcher
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