Lactoferrin and Raman/fluorescent technologies: the role in pathogenesis and the course of the inflammatory diseases of the female reproductive system

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In the review there is reflected the new look at the introduction into clinical microbiology new methods of diagnosis (such as Raman/Fluorescence Technology), which made it possible to enlarge micro-ecological investigations. Suppression of the normal vaginal microflora was found to lead to a variety of causes of the pathology of both inflammatory and non-inflammatory genesis. Iron-binding glycoprotein from the family of transferrin (lactoferrin) gives rise to the decrease of the inflammatory response of the body, it can be used in treatment of vulvovaginal candidiasis and bacterial vaginosis.

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About the authors

Dariya G. Gulenkova

I.M. Sechenov First Moscow State Medical University

Moscow, 119991, Russian Federation
postgraduate student of the Department of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University

Vladimir M. Zuev

I.M. Sechenov First Moscow State Medical University

Moscow, 119991, Russian Federation
Professor, Department of Obstetrics and Gynecology № 1 medical faculty I.M. Sechenov First Moscow State Medical University


  1. Montreuil J., Tonnelat J., Mullet S. Preparation et proprietes de la lactosiderophiline (lactotransferrine) du lait de femme. Biochim. Biophys. Acta. 1960; 45: 413-421.
  2. Houghton M.R., Gracey M., Burke V., Bottrell C., Spargo R.M. Breast milk lactoferrin levels in relation to maternal nutritional status. J. Pediatr. Gastroenterol. Nutr. 1985. 4: 230-3.
  3. Legrand D., Elass E., Carpentier M., Mazurie J. Lactoferrin: a modulator of immune and infl ammatory responses. Cell. Mol. Life Sci. 2005; 62 (22): 2549-59.
  4. Teng C.T., Beard C., Gladwell W. Differential expression and estrogen response of lactoferrin gene in the female reproductive tract of mouse, rat and hamster. Biol. Reprod. 2002; 67: 1439-49.
  5. Atsushi Yanaihara, Kaori Mitsukawa, B. Agr, Shinji Iwasaki, Katsufumi Otsuki, Toshihiro Kawamura, Takashi Okai. High concentrations of lactoferrin in the follicular fl uid corr elate with embryo quality during in vitro fertilization cycles. Fertil. and Steril. 2007; 87 (2): 279-82.
  6. Gonzalez-Chavez S.A., Arevalo-Gallegos S., Rascon-Cruz Q. Lactoferrin: structure, function and applications. Int. J. Antimicrob. Agents. 2009; 33 (4): 301.e1-8.
  7. Qiao Yuan, Chen Zhuo, Ma Yonggui, Lu Fuer, Chen Suhua, Huang Guangying. Nonoxynol-9 berberine plural gel has little effect on expression of SLPI, SP-D and lactoferrin in mice’s vagina. Iran. J. Reprod. Med. 2013; 11 (7): 565-76.
  8. Masson P.L., Heremans J.F., Schonne E. Lactoferrin, an iron-binding protein in neutrophilic leukocytes. J. Exp. Med. 1969; 130: 643-58.
  9. Metz-Boutigue M.H., Jolles J., Mazurier J., Schoentgen F., Legrand D., Spik G. et al. Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins. Eur. J. Biochem. 1984. 145 (3): 659-76.



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