METHODS OF PRECLINICAL DIAGNOSIS OF PREECLAMPSIA. COMPARISON OF BIOCHEMICAL AND INSTRUMENTAL METHODS OF EXAMINATION

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract


The review presents current information on the predictive diagnosis of preeclampsia. The data of instrumental and laboratory diagnostics are described. Laboratory diagnostics includes such biochemical markers as PAPP-A, PIGF, VEGF, sFlt-1, sEng, NSE; instrumental diagnostics consists of ultrasound evaluation of placental structure, ultrasound dopplerometry of uterine arteries and determination of the index of vascularization of the placenta. Not all methods of the examination presented by the author have diagnostic value in the clinical use. Biochemical markers present the most accurate diagnostic picture. It is necessary to evaluate sFlt-1, PIGF and other markers in dynamics since their change with the increase in the gestation age differs significantly from the change in those in women with normal pregnancy.

Full Text

Restricted Access

About the authors

Saida Kh. Eristova

I.M. Sechenov First Moscow State Medical University

Email: saidaeristova@gmail.com
Moscow, 119991, Russian Federation
a Sixth-year student of the I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation

References

  1. Сидорова И.С. Преэклампсия. М.: МИА; 2016.
  2. Радзинский В.Е., Фукс А.М., ред. Акушерство: учебник. М.: ГЭОТАР-Медиа; 2016.
  3. Conde-Agudelo A., Villar J., Lindheimer M. World Health Organization systematic review of screening tests for preeclampsia. Obstet. Gynecol. 2004;104 (6):1367-91.
  4. Сидорова И.С., Никитина Н.А. Научно обоснованная система прогнозирования преэклампсии. Акушерство и гинекология. 2017; 3: 55-61. doi: http://dx.doi.org/10.18565/aig.2017.3.55-61
  5. Хлестова Г.В., Карапетян А.О., Шакая М.Н., Романов А.Ю., Баев О.Р. Материнские и перинатальные исходы при ранней и поздней преэклампсии. Акушерство и гинекология. 2017; (6): 41-7. doi: https://dx.doi.org/10.18565/aig.2017.6.41-7
  6. Roberge S., Villa P., Nicolaides K., Vainio M. et al. Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis. Am. J. Perinatol. 2012; 29(7): 551-6. doi: 10.1055/s-0032-1310527
  7. Сковородина Т.В., Вишнякова П.А., Шмаков Р.Г., Высоких М.Ю. Роль митохондриальных маркеров в патогенезе преэклампсии и оценка эффективности респираторной терапии в лечении преэклампсии. Акушерство и гинекология. 2017; (6). doi: https://dx.doi.org/10.18565/aig.2017.6.5-9
  8. Cnossen J.S., Morris R.K., ter Riet G. et al. Use of uterine artery Doppler ultrasonography to predict preeclampsia and intrauterine growth restriction: a systematic review and bivariable meta-analysis. Can. Med. Assec. J. 2008;178(6): 01-11. doi: 10.1503/cmaj.070430
  9. Холин А.М., Муминова К.Т., Балашов И.С., Ходжаева З.С., Боровиков П.И., Иванец Т.Ю., Гус А.И. Прогнозирование преэклампсии в первом триместре: валидация алгоритмов скрининга на российской популяции. Акушерство и гинекология. 2017; (8): 74-84. doi: https://dx.doi.org/10.18565/aig.2017.8.74-84
  10. Lamarca B. Endothelial dysfunction. An important mediator in the pathophysiology of hypertension during preeclampsia. Minerva Ginecol. 2012; 64(4): 309-20.
  11. Carty D.M., Delles Ch., Dominiczak A.F. Novel biomarkers for predicting preeclampsia. Trends Cardiovasc. Med. 2008;18(5):186-94. doi: 10.1016/j.tcm.2008.07.002
  12. Сюндюкова Е.Г. Клинико-морфологическая характеристика фетоплацентарного комплекса при преэклампсии. Современные проблемы науки и образования. 2016; (3). URL: http://science-education.ru/ru/article/view?id=24604 (дата обращения).

Statistics

Views

Abstract - 46

PDF (Russian) - 0

Cited-By


Article Metrics

Metrics Loading ...

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies