COMPARATIVE EFFICACY OF HORMONAL DRUGS FOR THE PREPARATION OF THE ENDOMETRIUM FOR ABLATION IN PREMENOPAUSAL PATIENTS

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Abstract


The aim of the study is to compare the effectiveness of the use of hormonal drugs before hysteroresectoscopic ablation of the endometrium in premenopausal patients with abnormal uterine bleeding. Were examined 145 women aged from 45 to 54 years with recurrent endometrial hyperplasia, which were divided into three groups depending on the preoperative use of one of the hormonal drugs (gestagen preparation, microdose estrogen-gestagen contraceptive, gonadotropin-releasing hormone agonist - GnRHa). When medication-induced endometrial atrophy was achieved, the patients underwent hysteroresectoscopic endometrial ablation using the coagulation vaporization technique. The results of the study showed the feasibility of preoperative thinning of the uterine mucosa to improve the results of treatment of its benign changes. The most effective means for accelerating the attainment of drug regression of the endometrium were GnRHa, whose effectiveness was 95.7%. The estrogen-gestagen-containing contraceptive and gestagen preparation showed an efficacy of 65.3% and 42.8%, respectively. The results of the study should be considered when choosing the optimal tactics for management of premenopausal patients with abnormal uterine bleeding.

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About the authors

Sergey P. Sinchikhin

Astrakhan State Medical University

Email: doc_sinchihin@mail.ru
414000, Astrakhan, Russian Federation
Dr. med. Sci., Professor, Head of the Department of Obstetrics and Gynecology, Faculty of Medicine, “Astrakhan State Medical University”, 414000, Astrakhan

E. V Kostenko

Astrakhan State Medical University

414000, Astrakhan, Russian Federation

L. V Stepanyan

Astrakhan State Medical University

414000, Astrakhan, Russian Federation

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