Influence of ADRB2 gene polymorphism on the development of preterm birth in women of different ethnic groups

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Abstract


Preterm birth remains an acute medical and socio-economic problem. The successful course of pregnancy and its completion by timely delivery is directly dependent on an adequate balance of immune interactions between the mother and the fetus throughout the pregnancy, respectively, any failure of this system can lead to catastrophic consequences. The level of cytokine expression is genetically determined. Polymorphism of a gene affects the level of cytokines in its expression and functionality. Thus, polymorphism of cytokine genes can have an effect on the development of various pregnancy complications leading to its premature termination.


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About the authors

Gyuzel F. Proklova

I.M. Sechenov First Moscow State Medical University

Email: guzelp@mail.ru
ORCID iD: 0000-0003-3382-026X

Russian Federation, Moscow

Raisa A. Chilova

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: rchilova@gmail.com
ORCID iD: 0000-0001-6331-3109

Russian Federation, Moscow

MD, PhD, Prof., Associate prof. of the Department of Obstetrics and Gynecology of I.M. Sechenov First Moscow State Medical University, Moscow

Elena A. Sokova

Clinical Pharmacology Center “Scientific Center for Expertise of Medical Devices”, Ministry of Health of Russia

Email: sokova2@rambler.ru
ORCID iD: 0000-0002-6389-2099

Russian Federation, Moscow

MD, PhD

Ruslan E. Kazakov

Clinical Pharmacology Center “Scientific Center for Expertise of Medical Devices”, Ministry of Health of Russia

Email: rustic100@rambler.ru
ORCID iD: 0000-0003-0802-4229

Russian Federation, Moscow

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