Influence of ADRB2 gene polymorphism on the development of preterm birth in women of different ethnic groups

Cover Page
Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


Preterm birth remains an acute medical and socio-economic problem. The successful course of pregnancy and its completion by timely delivery is directly dependent on an adequate balance of immune interactions between the mother and the fetus throughout the pregnancy, respectively, any failure of this system can lead to catastrophic consequences. The level of cytokine expression is genetically determined. Polymorphism of a gene affects the level of cytokines in its expression and functionality. Thus, polymorphism of cytokine genes can have an effect on the development of various pregnancy complications leading to its premature termination.

Full Text

Restricted Access

About the authors

Gyuzel F. Proklova

I.M. Sechenov First Moscow State Medical University

ORCID iD: 0000-0003-3382-026X

Russian Federation, Moscow

Raisa A. Chilova

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
ORCID iD: 0000-0001-6331-3109

Russian Federation, Moscow

MD, PhD, Prof., Associate prof. of the Department of Obstetrics and Gynecology of I.M. Sechenov First Moscow State Medical University, Moscow

Elena A. Sokova

Clinical Pharmacology Center “Scientific Center for Expertise of Medical Devices”, Ministry of Health of Russia

ORCID iD: 0000-0002-6389-2099

Russian Federation, Moscow


Ruslan E. Kazakov

Clinical Pharmacology Center “Scientific Center for Expertise of Medical Devices”, Ministry of Health of Russia

ORCID iD: 0000-0003-0802-4229

Russian Federation, Moscow


  1. Plunkett J., Muglia L. Genetic contributions to preterm birth: Implications from epidemiological and genetic association studies. Ann. Med. 2008;40(3):167-79.
  2. Menon R., Fortunato S.J., Velez Edwards D.R., Williams S.M. Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations. Ann. Hum. Genet. 2010;74(2):165-83. doi: 10.1111/j.1469-1809.2010.00562.x
  3. Hamilton B.E., Hoyert D.L., Martin J.A., Strobino D.M., Guyer B. Annual summary of vital statistics: 2010–2011. Pediatrics. 2013; 131:548-58.
  4. Gómez L.M., Sammel M.D., Appleby D.H., Elovitz M.A., Baldwin D.A., Jeffcoat M.K. et al. Evidence of a gene-environment interaction that predisposes to spontaneous preterm birth: a role for asymptomatic bacterial vaginosis and DNA variants in genes that control the inflammatory response. Am. J. Obstet. Gynecol. 2010; 202(4):386.e1-6.
  5. Mathews T.J., MacDorman M.F. Infant mortality statistics from the 2003 period linked birth/infant death data set. Natl. Vital Stat. Rep. 2006;54:1-29.
  6. Blencowe H., Cousens S., Oestergaard M.Z., Chou D., Moller A.B., Narwal R., et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: A systematic analysis and implications. Lancet. 2012;379:2162-72.
  7. Ozkur M., Dogulu F., Ozkur A., Gokmen B., Inaloz S.S., Aynacioglu A.S. Association of the Gln27Glu polymorphism of the beta-2-adrenergic receptor with preterm labor. Int. J. Gynaecol. Obstet. 2002;77:209-15.
  8. Landau R., Xie H.G., Dishy V., et al. Beta-2 adrenergic receptor genotype and preterm delivery. Am. J. Obstet. Gynecol. 2002;187: 1294-8.
  9. Landau R., Morales M.A., Antonarakis S.E., Blouin J.L., Smiley R.M. Arg16 homozygosity of the beta-2 adrenergic receptor improves the outcome after beta-2 agonist tocolysis for preterm labor. Clin. Pharmacol. Ther. 2005;78:656-63.
  10. Crider K.S., Whitehead N., Buus R.M. Genetic variation associated with preterm birth: A HuGE review. Genet. Med. 2005;7:593-604.
  11. Kunihiko D., Istvan S., Santosh V. et al. β2-adrenergic receptor gene polymorphisms and pregnancy outcome. J. Perinat. Med. 2004;32: 413-7.
  12. Ríos J.C., McEwen J.G, Cuartas A. et al. Evaluación del efecto de cuatro polimorfismos en el gen del receptor adrenérgico β-2 en el parto pretérmino. Colomb. Med. 2008; 56:7-15.
  13. Miller R.S., Smiley R.M., Daniel D., Weng Ch. Beta-2 adrenoceptor genotype and progress in term and late preterm active labor. Am. J. Obstet. Gynecol. 2011;205:137.e1-7.
  14. Park J.Y., Lee N.R., Lee K.E., Park S., Kim Y.J., Gwak H.S. Effects of β2-adrenergic receptor gene polymorphisms on ritodrine therapy in pregnant women with preterm labor: prospective follow-up study. Int. J. Mol. Sci. 2014;15:12885-94.
  15. Серов В.Н., Тютюнник В.Л. Тактика лечения угрожающих преждевременных родов. Руc. мед. журн. 2008;16(19):1252-5. [Serov V.N., Tyutyunnik V.L. Tactics of treatment of threatening premature birth. Russkiy meditsinskiy zhurnal. 2008;16(19):1252-5. (In Russ.)]



Abstract - 55

PDF (Russian) - 0


Article Metrics

Metrics Loading ...


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies