Chronic endometritis and its impact on female reproductive function

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Abstract


Chronic endometritis is a local inflammatory disease characterized by the presence of plasma cells in endometrial stroma regardless of menstrual cycle phase. This diagnosis can be confirmed based only on morphological examination of endometrial biopsy what makes this diagnosis difficult to prove in clinically healthy patients who can not get pregnant or carry a child. According to statistics of the past five years, more than 30% women of reproductive age having repeated implantation failures in IVF cycles and recurrent miscarriages are diagnosed with chronic endometritis. Since this pathology is related to long persistence of microbial associations in uterine cavity, the gold standard of treatment is antibacterial therapy. It is elucidated that during a year after antibiotic treatment the rate of spontaneous pregnancy is increased in more than 60% women compared with women who do not receive treatment regarding chronic endometritis.


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About the authors

Marina O. Silkina

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: mari5555@yandex.ru
ORCID iD: 0000-0001-6454-1963
SPIN-code: 2342-3129
Scopus Author ID: 504021

Russian Federation, Moscow

VI-year student of the Medical Faculty No 1 of the I.M. Sechenov First Moscow State Medical University (Sechenov University)

Elena A. Sosnova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: sosnova-elena@inbox.ru
ORCID iD: 0000-0002-1732-6870
SPIN-code: 6313-9959
Moscow

MD, PhD, Professor

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