The possibility of prediction of early neonatal death

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Abstract


The most important tasks facing obstetricians-gynecologists and neonatologists include reducing early neonatal mortality. One of the ways to solve the problem is to predict early neonatal death in the first day after birth.

In order to identify possible predictors of early neonatal death, a retrospective study was conducted that included 99 women whose children died in the first 168 hours after birth (main group) and 357 women without early neonatal losses (control group).

In the first 2–3 days after birth, the delivery period, the features of the birth act, the condition of the mother and newborn baby, including the data of a clinical blood test, morphometric and histological examination of the placenta, were determined and described for the both groups.

Based on the analysis of these data, the following statistically significant differences were revealed for puerperas and newborns of the main group: premature birth; delivery in the pelvic presentation; malnutrition of the fetus/newborn; shorter duration of the first stage of labor, a longer duration of the second and third periods of labor; higher frequency of perineal dissection, manual examination of the uterine cavity, blood transfusion for puerperas; smaller mass and growth of newborns, lower Apgar score on the 1st and 5th minute; leukocytosis and thrombocytopenia in a blood test in puerperas, a lower level of hemoglobin, erythrocytes and platelets and an higherlevel of the glucose of venous blood in newborns; the following structural features of the placenta: hematogenous viral and ascending bacterial infection and their combination, acute placental and umbilical cord failure, sub- and decompensated chronic placental insufficiency.

These indicators may be predictors of early neonatal death.


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About the authors

Vitaly F. Bezhenar

First Saint Petersburg state medical University named after acad. I.P. Pavlov Ministry of health of the Russian Federation

Email: bez-vitaly@yandex.ru
ORCID iD: 0000-0002-7807-4929

Russian Federation, Saint Petersburg

MD, PhD, Professor

Lidiya A. Ivanova

S.M. Kirov Military Medical Academy of the Ministry of defense of the Russian Federation

Author for correspondence.
Email: lida.ivanova@gmail.com
ORCID iD: 0000-0001-6823-3394

Russian Federation, Saint Petersburg

Cand. Sci. Med., Associate prof. of the Department of Obstetrics and Gynecology, S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation

Alexey N. Drygin

First Saint Petersburg state medical University named after acad. I.P. Pavlov Ministry of health of the Russian Federation

Email: 79112286592@mail.ru
ORCID iD: 0000-0002-3322-8701

Russian Federation, Saint Petersburg

MD, PhD, Professor

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Supplementary files

Supplementary Files Action
1.
Fig. 1. The mass of newborn children who died in the first 7 days of extrauterine life in the Leningrad region in 2006–2018.

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2.
Fig. 2. The mass of newborns who died in the first 7 days of extrauterine life in St. Petersburg in 2006–2018.

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