Maternal factors of preconceptual and early gestation periods in women with high prenatal diagnostic risks

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Objective — evaluate maternal factors in preconception and early gestation periods in women with a high risk of prenatal diagnosis.

Methods and patients. Features of the development of preconception and early gestation periods were studied, including the first prenatal screening (PS), in 443 women with singleton pregnancy. Women were divided into 2 clinical groups: group 1 (n = 235) with a high risk (HR) of complications; subgroups: 1A (n = 69) — fetal chromosomal abnormalities (after exclusion confirmed cases); 1B (n = 66) — the development of preeclampsia; 1C (n = 48) — fetal growth restriction; 1D (n = 52) — preterm birth (PB). 2nd control group (n = 208) — women with low risk of complications.

Results. A high PS risk in the 1st group, especially in subgroups 1A, 1B, were in patients with hypertonic disease of 1-2 degrees (p < 0.05). Chronic kidney disease was leading in 1A, 1C (p < 0.05). Varicose veins of the lower extremities in the 1st group prevailed in the 1A, 1B, 1C (p < 0.05). A history of ovarian tumors and uterine myoma during pregnancy prevailed in 1A, 1B, cycle dysfunction in 1B, 1D (p < 0.05). GR was observed in nulliparous women with a history of miscarriages in 1B, 1C, 1D and artificial abortions in 1A (p < 0.05). PB in the anamnesis were significantly increased in the 1st gr. (p < 0.001). In the 1st trimester, the threatened miscarriage, bleeding and progesterone were frequent in the 1st group (p < 0.05).

Conclusion. Based on the obtain results a high risk of PS calculated according to the Astraia program using standard markers was noted in patients with somatic pathology, ovarian tumors, miscarriages, medical abortions and PB in the anamnesis, myoma during pregnancy, threatened miscarriage, bleeding, progesterone intake during 1st trimester. These factors should be considered when preparing for pregnancy.

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About the authors

Petr M. Samchuk

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
ORCID iD: 0000-0001-7882-8922

Russian Federation, Moscow

MD, PhD, DSci. in medicine, professor at the chair Obstetrics and Gynecology No. 1, I.M. Sechenov First Moscow State Medical University (Sechenov University)

Evelina L. Azoyeva

V.V. Veresayev City Clinical Hospital

ORCID iD: 0000-0002-3711-2423

Russian Federation, Moscow

Anatoliy I. Ishchenko

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID iD: 0000-0003-3338-1113

Russian Federation, Moscow

MD, PhD, DSc, Professor


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