Cytokine status and availability of vitamin d in women with miscarriage of infectious genesis

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In recent years, there have been reports of the role of vitamin D deficiency in the development of inflammatory processes of various localization associated with the prolonged persistence of infectious agents and its effect on the implementation of the immune response.

The objective — to assess the condition of cytokine status and the availability of vitamin D in pregnant women with miscarriage and urogenital infection to improve prognostications and prevention of complications in obstetrics.

Material and methods. We examined 106 pregnant women in the I–II trimester of pregnancy: 76 pregnant women with miscarriage (the main group) and 30 women with a physiological pregnancy progression (the control group) with the determination of their serum vitamin D level by high-performance liquid chromatography (HPLC), diagnostics of urogenital infection and immunity indicators with the determination of serum cytokines.

Results and discussion. According to the results of the study, it was found that the level of vitamin D in the blood below 20 ng/ml is more often accompanied by miscarriage. Correlation analysis confirmed the presence of a relationship between cytokine production and the level of vitamin D in the blood of pregnant women.

Conclusion. Normalization of vitamin D levels in the blood can help to reduce the risk of miscarriage.

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About the authors

Tat’yana N. Savchenko

N.I. Pirogov Russian National Research Medical University

ORCID iD: 0000-0001-7244-4944
SPIN-code: 3157-3682

Russian Federation, Moscow

MD, PhD, Professor

Lyudmila A. Ozolinya

N.I. Pirogov Russian National Research Medical University

Author for correspondence.
ORCID iD: 0000-0002-2353-123X
SPIN-code: 9407-9014

Russian Federation, Moscow

MD, Ph.D., DSci., Professor of the Department of Obstetrics and Gynecology, Medical Faculty of the N.I. Pirogov Russian National Research Medical University

Irina A. Dergacheva

N.I. Pirogov Russian National Research Medical University

ORCID iD: 0000-0002-3049-6954
SPIN-code: 5135-8612

Russian Federation, Moscow

Ekaterina N. Polovinkina

N.I. Pirogov Russian National Research Medical University

ORCID iD: 0000-0002-0686-2790
SPIN-code: 2494-9131

Russian Federation, Moscow

Marina S. Safonina

N.I. Pirogov Russian National Research Medical University

ORCID iD: 0000-0003-4252-4024
SPIN-code: 2997-4580

Russian Federation, Moscow


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Supplementary files

Supplementary Files Action
Fig. 1. The level of vitamin D in the examined pregnant women,%.

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Fig. 2. Pregnancy outcomes in the examined patients of the main and control groups,%.

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