V.F.Snegirev Archives of Obstetrics and GynecologyV.F.Snegirev Archives of Obstetrics and Gynecology2313-87262687-1386Eco-Vector3478610.17816/2313-8726-2020-7-2-102-107Research ArticleThe role of magnesium in the treatment of premenstrual syndromeOzolinyaLyudmila A.<p>MD, PhD, Professor</p>ozolinya@yandex.ruhttps://orcid.org/0000-0002-2353-123XOverkoAleksey V.leha.overko@yandex.ruBakhodurovaKhushnuda A.xbaxodurova@mail.ruN.I. Pirogov Russian National Research Medical University180620207210210718062020Copyright © 2020, Eco-Vector2020<p>65 patients with premenstrual syndrome (PMS) participated in a clinical, laboratory, and instrumental study that included determining the level of magnesium in the blood serum, two groups of them were formed. All subjects received symptomatic therapy for PMS, but the patients of group 1 (32 people) were prescribed magnesium citrate with vitamin B<sub>2</sub> (Riboflavin) orally for 2 months, and patients of the 2nd group (33 people) only vitamin B<sub>2</sub>. In group 1 patients, the number of PMS symptoms significantly decreased. Patients of the 2nd group, after ineffective treatment with vitamin B<sub>2</sub>, were additionally prescribed magnesium citrate after 2 months, which led to a positive effect. As a result of treatment with magnesium citrate with vitamin B<sub>2</sub>, the frequency of symptoms such as anxiety, depression, resentment, tearfulness, and headache significantly decreased. The decrease in the frequency of other PMS symptoms was not statistically significant. There were no significant changes in the level of magnesium concentration in the blood serum.</p>premenstrual syndromemagnesium deficiencymagnesium citratevitamin B2 (Riboflavin)предменструальный синдромдефицит магнияцитрат магниявитамин В2 (рибофлавин)[Громова О.А., Серов В.Н., Торшин И.Ю. Магний в акушерстве и гинекологии: история применения и современные взгляды. Трудный пациент. 2008; (8):10-5.][Савельева Г.М., Сухих Г.Т., Серов В.Н., Радзинский В.Е., Манухин И.Б., ред. Гинекология: Национальное руководство. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа; 2017: 231-6.][Серов В.Н., Сухих Г.Т., Прилепская В.Н., Радзинский В.Е., ред. Руководство по амбулаторно-поликлинической помощи в акушерстве и гинекологии. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа; 2016.][Магний Диаспорал 300: инструкция к препарату. Регистр лекарственных средств России. www.md300.ru дост. 01.02.20.][Barbagallo M., Dominquez L.J. Magnesium metabolism in type 2 diabetus mellitus, metabolic syndrome and insulinresistence. Arch. Biochem. Biophys. 2007; 458(1): 40-7.][He K., Liu K., Daviglus M.L. et al. Magnesium intake and incidence of metabolic syndrome among young adult. Circulation. 2006;113 (13): 1675-82.][Randell E.W., Mathews M., Gadag V. et al. Relationship between serum magnesium values, lipids and anthropometric risk factors. Atherosclerosis. 2008; 196 (1): 413-9.][Takaya J., Higashino H., Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes. Res. 2004; 17(2): 126-6.][Moos R.H. The development of menstrual distress questionnaire. Psychosom. Med. 1968; 30: 853-68.][Koseoglu E., Talaslioglu A., Gonul A.S., Kula M. The effects of magnesium prophylaxis in migraine without aura. Magnes. Res. 2008; 21: 101-8.][Tepper S.J. Treatment of menstrual migraine: evidence-based review. Manag. Care. 2007; 16: 10-4; discussion 5-7.][Parazzini F., Di Martino M., Pelligrino P. Magnesium in the gynecological practice: a literature review. Magnes. Res. 2017; 30(1): 1-7.][Ventskivska I.B., Senchuk A. Role of magnesium in the pathogenesis of premenstrual disorders. Lik Sprava. 2005; (8): 62-5.][Quaranta S., Buscaglia M.A., Meroni M.G., Colombo E., Cella S. Pilot study of the efficacy and safety of a modified-release magnesium 250 mg tablet (Sincromag) for the treatment of premenstrual syndrome. Clin. Drug. Inv. 2007; 27 (1): 51-8.][Marjoribanks J., Brown J., O’Brien P.M., Wyatt K. Selective serotonin reuptake inhibitors for premenstrual syndrome. Cochrane Database Syst. Rev. 2009; 2: CD001396.][Facchinetti F., Borella P., Sances G., Fiodoni L., Nappi R.E., Genazzani A.R. Oral magnesium successfully relieves premenstrual mood changes. Obstet. Gynecol. 1991; 78 (2):177-81.]