V.F.Snegirev Archives of Obstetrics and GynecologyV.F.Snegirev Archives of Obstetrics and Gynecology2313-87262687-1386Eco-Vector35254Research ArticleClinical significance of endothelial dysfunction in pregnancy as a component of comprehensive evaluation of pre-eclampsia riskDikurO. Nоxana.dikur@gmail.comKopylovF. Yu-I.M. Setchenov First Moscow Medical University151220141271321072020Copyright © 2014, Eco-Vector2014Vascular endothelium dysfunction is an important component of the pathogenesis of pre-eclampsia - one of the leading causes of maternal morbidity and mortality, perinatal deaths, and intrauterine development of small-for-date fetuses. Evaluation of the vascular endothelium status during gestation is a promising method for predicting the development of this condition. This paper presents a critical review of the major clinical studies of the prognostic significance of endothelial dysfunction markers, aimed at prediction ofpre-eclampsia. Modern methods for evaluating the endothelial function, including detection of biochemical markers of endothelial dysfunction and functional tests for evaluating the endothelium-dependent vasodilatation, are described. The significance of the best studied specific markers of gestosis, such as soluble fms-like tyrosine kinase-1, soluble endoglin, placental growth factor, for the prognosis and diagnosis ofpre-eclampsia is discussed.pre-eclampsiaendothelial dysfunctionendothelium-dependent vasodilatationпреэклампсияэндотелиальная дисфункцияэндотелийзависимая вазодилатация[Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009; 33 (3): 130-7.][Carty D.M., Delles C., Dominiczak A.F. Preeclampsia and future maternal health. J. Hypertens. 2010; 28 (7): 1349-55.][Maynard S.E., Karumanchi S.A., Thadhani R. Hypertension and kidney disease in pregnancy. In: Brenner B.M., eds. Brenner and Rector's The Kidney. 8th ed. 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