V.F.Snegirev Archives of Obstetrics and GynecologyV.F.Snegirev Archives of Obstetrics and Gynecology2313-87262687-1386Eco-Vector35270Research ArticlePerinatal aspects of papillomavirus infectionBaranovskayaE. Ielena_baranovska@mail.ruKustovaM. A-ZhavaranakS. V-Belorussian State Medical UniversityGomel State Medical University1506201522263021072020Copyright © 2015, Eco-Vector2015The aim of this study was detection of the clinical and virological factors contributing to infection of the placenta and newborn’s airways by human papillomavirus (HPV). The HPV DNA was detected in 98 pregnant women, puerperae and their newborns, distributed into three hroups: 1) (n = 57) patients with abnormal cervix uteri or genital papillomatosis; 2) (n = 18) patients with HIV infection; and 3) control (n = 23). The HPV DNA was isolated from the genital tract in 84.2, 61.1, and 39.1% pregnant women in groups 1, 2, and 3, respectively, and was associated with abnormalities of the cervix uteri and genital papillomatosis. A total of 84% placentas were infected mainly by the same genotype of HPV, associated with vaginitis, cervix uteri disease and genital papillomatosis, cervical intraepithelial neoplasia, small for date fetus, and hydramnion. The number of HPV genotypes in the genital tract and the maternal viral charge determined the infection of the placenta and newborn’s airways.human papillomaviruscervical intraepithelial neoplasiapregnancyplacentaвирус папилломы человекадисплазия шейки маткибеременностьплацента[Syrja S. Current concepts on human papillomavirus infections in children. APMIS. 2010; 118 (6-7): 494-509.][Rombaldi R.L., Serafi ni E.P., Mandelli J., Zimmermann E., Losquiavo K.P. Transplacental transmission of human papillomavirus. Virol. J. 2008; 5: 106-10.][Долгушина Н.В., Макацария А.Д. Вирусные инфекции у беременных. М.: «Триада-Х»; 2011.][Uribarren-Berrueta O., Sanchez-Corona J., Montoya-Fuentes H., Trujillo-Hernández B., Vásquez C. Presence of HPV DNA in placenta and cervix of pregnant Mexican women. Arch. Gynecol. Obstet. 2012; 285 (1): 55-60.][Zuo Z., Goel S., Carther J.E. Association of cervical cytology and HPV DNA status during pregnancy with placental abnormalities and preterm birth. Am J Clin Pathog. 2011; 136(2): 260-5.][Gomez L.M., Ma Y., Ho C., McGrath C.M., Nelson D.B., Par ry S. Placental infection with human papillomavirus is asso cia ted with spontaneous preterm delivery. Hum Reprod. 2008; 23(3): 709-15.][Sarkola M.E., Grenman S.E., Rintala M.A., Syrjänen K.J., Syrjänen S.M. Human papillomavirus in the placenta and umbilical cord blood. Acta Obstet. Gynecol. Scand. 2008; 87 (11): 1181-8.]