V.F.Snegirev Archives of Obstetrics and GynecologyV.F.Snegirev Archives of Obstetrics and Gynecology2313-87262687-1386Eco-Vector3546310.18821/2313-8726-2018-5-2-97-100Research ArticleMARKERS OF ANTIOXIDANT PROTECTION SYSTEM IN DIAGNOSTICS OF EXTERNAL GENITAL ENDOMETRIOSIS IN INFERTILITY FEMALE PATIENTSKhatlamadzhiyanM. G-KharitonovaE. V-AnisimovaU. S-ShcherbakovaLiya N.MD, PhD, associate professor of the Department of Obstetrics and Gynecology of the Faculty of Fundamental Medicine of the M.V. Lomonosov Moscow State University, Moscow, 119234, Russian Federationliya.fbm@gmail.comBugerenkoA. E-KalenikovaE. I-PaninaO. B-M.V. Lomonosov Moscow State University15062018529710021072020Copyright © 2018, Eco-Vector2018To identify markers of the antioxidant defense, 43 female patients with the infertility associated with external genital endometriosis were examined. The control group consisted of 19 healthy fertile women. In endometriosis patients, a statistically significant (p < 0.01) plasma level of coenzyme Q10 and α-tocopherol, determined by means of high-performance liquid chromatography with electrochemical detection, were noted to be lower in the comparison with the control group. On the basis of the data obtained, there was developed a prognostic scale that allows verifying the presence and severity of external genital endometriosis in infertility female patients.infertilityendometriosisantioxidant protectioncoenzyme Q10α-tocopherolбесплодиеэндометриозантиоксидантная защитакоэнзим Q10α-токоферол[Macer M.L., Taylor H.S. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet. Gynecol. Clin. North. Am. 2012; 39(4): 535-49.][Ozkan S., Murk W., Arici A. Endometriosis and infertility: epidemiology and evidence-based treatments. Ann. N. Y. Acad. Sci. 2008; 1127: 92-100.][Ищенко А.И., Кудрина Е.А., Станоевич И.В., Бахвалова А.А., Ромаданова Ю.А. Современные проблемы наружного генитального эндометриоза. Акушерство и гинекология. 2007; 5: 67-73][Fassbender A., Vodolazkaia A., Saunders P., Lebovic D., Waelkens E., De Moor B. et al. Biomarkers of endometriosis. Fertil. Steril. 2013; 99(4): 1135-45.][Mehedintu C., Plotogea M.N., Ionescu S., Antonovici M. Endometriosis still a challenge. J. Med. Life. 2014; 7(3): 349-57.][Carneiro M.M., Filogonio I.D., Costa L.M., de Avila I., Ferreira M.C. Clinical prediction of deeply infiltrating endometriosis before surgery: is it feasible? A review of the literature. Biomed. Res. Int. 2013; 2013: 1-8. doi: 10.1155/2013/564153][Signorile P.G., Baldi A. New evidence in endometriosis. Int. J. Biochem. Cell. Biol. 2015; 60: 19-22.][Agarwal A., Aponte-Mellado A., Premkumar B.J., Shaman A., Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod. Biol. Endocrinol. 2012; 10: 49. doi: 10.1186/1477-7827-10-49.][Augoulea A., Mastorakos G., Lambrinoudaki I., Christodoulakos G., Creatsas G. The role of the oxidative-stress in the endometriosis-related infertility. Gynecol. Endocrinol. 2009; 25 (2): 75-81.][Carvalho L.F., Samadder A.N., Agarwal A., Fernandes L.F., Abrao M.S. Oxidative stress biomarkers in patients with endometriosis: systematic review. Arch. Gynecol. Obstet. 2012; 286 (4): 1033-40.][Gupta S., Goldberg J.M., Aziz N., Goldberg E., Krajcir N., Agarwal A. Pathogenic mechanisms in endometriosis-associated infertility. Fertil. Steril. 2008; 90 (2): 247-57.][Дубинская Е.Д., Гаспаров А.С., Фёдорова Т.А., Лаптева Н.В. Роль генетических факторов, системы детоксикации и оксидативного стресса при эндометриозе и бесплодии (обзор литературы). Вестник РАМН. 2013; 8: 14-9.][Адамян Л.В., Бургова Е.Н., Сонова М.М., Осипова А.А., Арсланян К.Н., Поддубная О.Н. Окислительный стресс и генитальный эндометриоз. Проблемы репродукции. 2008; 4: 6-9.][Ngo C., Chereau C., Nicco C., Weill B., Chapron C., Batteux F. Reactive oxygen species controls endometriosis progression. Am. J. Pathol. 2009; 175 (1): 225-34][Кузнецова И.В. Роль окислительного стресса и антиоксидантной защиты в репродукции человека. Акушерство и гинекология. 2016; 3: 116-21.][Меньщикова Е.Б., Ланкин В.З., Зенков Н.К. Окислительный стресс. Прооксиданты и антиоксиданты. М.: Слово; 2006.][Genova M.L., Lenaz G. New developments on the functions of coenzyme Q in mitochondria. Biofactors. 2011; 37(5): 330-54.][Morre D.J., Morre D.M. Non-mitochondrial coenzyme Q. Biofactors. 2011; 37(5): 355-60.][Hargreaves I.P. Coenzyme Q10 as a therapy for mitochondrial disease. Int. J. Biochem. Cell. Biol. 2014; 49: 105-11.][Kalenikova E.I., Gorodetskaya E.A., Kolokolchikova E.G. Chronic administration of coenzyme Q(10) limits postinfarct myocardial remodeling in rats. Biochemistry (Moscow). 2007; 72(3): 332-8.][Prieto L., Quesada J.F., Cambero O., Pacheco A., Pellicer A., Codoceo R. et al. Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis. Fertil. Steril. 2012; 98(1): 126-30.][Awonuga A.O., Belotte J., Abuanzeh S., Fletcher N.M., Diamond M.P., Saed G.M. Advances in the pathogenesis of adhesion development: the role of oxidative stress. Reprod. Sci. 2014; 21(7): 823-36.][Iwabuchi T., Yoshimoto C., Shigetomi H., Kobayashi H. Oxidative stress and antioxidant defense in endometriosis and its malignant transformation. Oxid. Med. Cell. Longev. 2015; 2015: 848595.]