V.F.Snegirev Archives of Obstetrics and GynecologyV.F.Snegirev Archives of Obstetrics and Gynecology2313-87262687-1386Eco-Vector5695310.17816/2313-8726-2020-7-4-195-200Research ArticleProduction of some angiogenic factors and cytokines during physiological and complicated pregnancy, depending on the fetus sexBotashevaT. L.t_botasheva@mail.ruhttps://orcid.org/0000-0001-5136-1752RymashevskiyA. N.rymashevskyan@mail.ruhttps://orcid.org/0000-0003-3349-6914MikhelsonA. F.michelson.a.f@mail.ruhttps://orcid.org/0000-0002-6792-0982FabrikantA. D.annutka944@mail.ruhttps://orcid.org/0000-0002-4376-8111KhloponinaA. V.annakhloponina@yandex.ruhttps://orcid.org/0000-0002-2056-5231ZheleznyakovaE. V.elena.Gel.1961@yandex.ruhttps://orcid.org/0000-0003-4496-6387ZavodnovO. P.ozz2007@mail.ruhttps://orcid.org/0000-0002-9555-226727122020741952002612202026122020Copyright © 2020, Eco-Vector2020<p><strong><em>Objective</em></strong> <em>of the study was to evaluate the levels of certain vascular-endothelial factors and cytokines in women at various stages of uncomplicated pregnancy, depending on the gender of the fetus.</em></p>
<p><strong><em>Materials and methods.</em></strong><em> 1101 pregnant women were examined. Group 1</em><em><sup>st</sup></em><em> with physiological pregnancy included 584 women, among them 280 women were pregnant with female fetuses and 304 were pregnant with male fetuses. Group 2</em><em><sup>nd</sup></em><em> with placental dysfunction included 517 pregnant women (253 pregnant women with female fetuses and 264 with male fetuses). Serum levels of epidermal growth factor (EGF), vascular endothelial growth factor A (VEGF-A), tumor necrosis factor </em><em></em><em> (TNF-</em><em></em><em>), placental growth factor (PLGF), endothelin-1 (ET-1) and interleukins (IL-1, IL-6, IL-10, IL-12) were determined using ELISA method in the second and third trimesters of pregnancy.</em></p>
<p><strong><em>Results.</em></strong><em> Statistically significant differences in the levels of some angiogenic factors and cytokines were revealed in pregnant women with uncomplicated gestation and placental dysfunction, depending on the sex of the fetus: in the case of the female gender, their higher levels were revealed, which indicates a more pronounced activity of the mothers immune system during gestational adjustment with this form of fetal gender. With placental dysfunction, a decrease in the levels of certain cytokines is noted.</em></p>sex of the fetusangiogenic factorscytokinesuncomplicated physiological pregnancyutero-placental-fetal complex.пол плодаангиогенные факторыцитокинынеосложнённая физиологическая беременностьматочно-плацентарно-плодовый комплекс.[Abdullayeva OI, Abzalova ShR, Akhmedova ShU, Daminova MN, Kapranov SV, Kapranova TS, et al. Modern aspects of endocrinology and immunology. Novosibirsk; 2015. 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