Current diagnostic methods of monoclonal gammopathy (literature review)

Abstract


The article is a review of the clinical diagnostic and laboratory data obtained in different research laboratories. Criteria of diagnosis of various monoclonal gammopathy. Reflects current diagnostic laboratory methods. Particular attention is paid to the method of determination of free light chains of serum immunoglobulins by the "Freelight", which has a high sensitivity and specificity.

Full Text

Современные методы диагностики моноклональных гаммапатий (обзор литературы)

About the authors

E V Anisimova


E V Anisimova


References

  1. Kuhnemund A., Liebisch P., Bauchmuller K. et al. «Light-chain escape – multiple myeloma» // J. Cancer Res. Clin. Oncol. 2009. 135. (3). 477-484.
  2. Serum free light chain analysis / Ed. A. R. Bredwell. Birmingem, 2006.285p.
  3. Голенков А.К., Митина Т.А., Луцкая Т.Д. и др. Клиническое значение анализа свободных лёгких цепей иммуноглобулинов сыворотки при множественной миеломе с различным ответом на химиотерапию // Рос. биотерапевтич. журн. 2007. №3. Т.6. 71-74.
  4. Любимова Н.В. и др. Современный иммунохимический метод определения содержания свободных лёгких цепей иммуноглобулинов в сыворотке крови Тбольных моноклональными гаммапатиями // Бюллетень СО РАМН. Т.31. №2, 2011 г. 64-70
  5. Bradwell AR, Carr-Smith HD, Mead GP, et al. Serum test for assessment of patients with Bence Jones myeloma. Lancet. 2003;361:489–491.
  6. Hassoun H, Rafferty BT, Flombaum C, et al. High dose chemotherapy and autologous stem cell transplantation with melphalan in patients with monoclonal immunoglobulin deposition disease associated with multiple myeloma. Blood. 2007;110:360b.
  7. Katzmann JA, Clark RJ, Abraham RS, et al. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: Relative sensitivity for detection of monoclonal light chains. Clin Chem. 2002;48:1437–1444
  8. Katzmann JA, Dispenzieri A, Kyle RA, et al. Elimination of the need for urine studies in the screening algorithm for monoclonal gammopathies by using serum immunofixation and free light chain assays. Mayo Clin Proc. 2006;81:1575–1578.
  9. Bochtler T, Hegenbart U, Heiss C, et al. Evaluation of the serum-free light chain test in untreated patients with AL amyloidosis. Haematologica. 2008;93:459–462
  10. Lachmann HJ, Gallimore R, Gillmore JD, et al. Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy. Br J Haematol. 2003;122:78–84.

Statistics

Views

Abstract - 32

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c) 2013 Anisimova E.V., Anisimova E.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies