An evaluation of the influence of angionensinogen gene M235T polymorphism on the development of essential arterial hypertension with the workers of locomotive teams

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In the article there's a comparative estimation of the influence of angionensinogen gene polymorphism on the development of essential arterial hypertension with the workers of locomotive teams. The main external factors of essential arterial hypertension are closely connected with the psychoemotional stress, and within the engine-drivers and engine-drivers mates, who has the high stress level profession, essential arterial hypertension is a professional disease. In our investigation we included 105 workers of locomotive teams with essential arterial hypertension who were treated at the Arterial hypertension center of Samara railway station hospital based on the Russian railways. The material of investigation was the blood serum of the patients and genomic desoxyrhybonuclear acid. Resulting our investigation it was established that M235T polymorphism is associated with essential arterial hypertension of the workers of locomotive teams. Genetic marker that was revealed serves as criteria of essential hypertension diagnostics and helps purposefully to select the patients that need the primary prevention.

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O N Obydennikova



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