Email this article A complex evaluation of a functional condition of kidneys in children with chronic kidneys disease
- Authors: Borisova OV1
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Affiliations:
- Issue: Vol 11, No 1-2 (2011)
- Pages: 75-81
- Section: Articles
- URL: https://aspvestnik.ru/2410-3764/article/view/24887
- DOI: https://doi.org/10.17816/2072-2354.2011.0.1-2.75-81
- ID: 24887
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Abstract
Decrease of the renal functions plays a considerable role in pathogenesis of chronic kidneys disease (CKD). Among set of diagnostic technologies we were interested by a complex estimation of a functional condition of kidneys (FCK) at children with CKD.
424 children with chronic diseases of kidneys are surveyed: 135 children with glomerulonephritis (GN), 122 patients with a pyelonephritis (PN) and 167 patients with tubulointerstitial nephritis (TIN). Indicators of functional condition of the kidney at children are estimated in 1 year, 3 and 5 years after the acute period. Mathematical modeling of a condition of nephritic functions is spent by a method of the system multiple-factor analysis (SМА).
At the patients with GN the infringement of renal functions occurred mainly at the expense of glomerular component (decrease in speed of a glomerular filtration). At the patients with PN and TIN the infringement of renal functions occurred at the expense tubular component (decrease of the concentration ability, parameters of acido-and ammoniogenesis, β2-microglobulines, increase diurnal proteinuria). The estimation of nephroscintigrams has confirmed the obtained data. SMA has shown the infringement of the kidney functional condition, the calculated weight factors and integrated indicators reflected glomerular and tubular disfunction at CKD.
424 children with chronic diseases of kidneys are surveyed: 135 children with glomerulonephritis (GN), 122 patients with a pyelonephritis (PN) and 167 patients with tubulointerstitial nephritis (TIN). Indicators of functional condition of the kidney at children are estimated in 1 year, 3 and 5 years after the acute period. Mathematical modeling of a condition of nephritic functions is spent by a method of the system multiple-factor analysis (SМА).
At the patients with GN the infringement of renal functions occurred mainly at the expense of glomerular component (decrease in speed of a glomerular filtration). At the patients with PN and TIN the infringement of renal functions occurred at the expense tubular component (decrease of the concentration ability, parameters of acido-and ammoniogenesis, β2-microglobulines, increase diurnal proteinuria). The estimation of nephroscintigrams has confirmed the obtained data. SMA has shown the infringement of the kidney functional condition, the calculated weight factors and integrated indicators reflected glomerular and tubular disfunction at CKD.
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