Diagnostic and prospective value of serum and intracellular cytokines in children and teenagers suffered from different types of juvenile idiopathic arthritis

Abstract


For the diagnosis specification of juvenile idiopathic arthritis and the determination of the importance of pathogenetic changes the research of parameters humor immunity, which are the most informative, is shown in the given pathology, namely: a spectrum cytokines: TNF α, IL6, IL1β, IL4, a level of spontaneous both stimulation lymphocytes and monocytes IL1β. Cytokines value is a main factor in an inductive phase of the immune answer when they cause the development of base reactions of makrophages and antigenspecificaition cells: interaction of these cells with lymphocytes, activation and proliferation the latter, in the certain degree the formation of cells effectors. At late stages of the immune answer, during the realization of effector immunity functions the role cytokines becomes less significant. The level both stimulations lymphocytes and monocytes IL1β reflects the activity of the pathological process and can be used in forecasting outcomes of juvenile idiopathic arthritis.

Full Text

Диагностическая и прогностическая значимость сывороточных и внутриклеточных цитокинов у детей и подростков, больных различными вариантами ювенильного идиопатического артрита

About the authors

S A Pyrkova


S A Goryunov


References

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Copyright (c) 2011 Pyrkova S.A., Goryunov S.A.

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