The connection of the genetic factor with clinical, metabolic and immunological characteristics of the patients with psoriasis

Abstract


The article presents the results of the examination of 104 patients ranging in age from 18 to 65, who were given in-patient and out-patient treatment for psoriasis within 2005/2008 in the Republican Dermatovenerologic Dispensary, Municipal Dermatovenerologic Dispensary and “Cosmetological clinic” Ltd. situated in Ufa. The patients were males 76 (73.1%) and females 28 (26,9 %) respectively. The average age of the patients equaled 41.2 ± 2.3. The dependence of clinical, metabolic and immunological characteristics on the genetic factor has been analyzed. It has been found out that statistically genetic predisposition to psoriasis significantly depends on patients’ younger age of disease onset, relative level of concentration of lymphocytes and CD8+ lymphocytes in patients’ peripheral blood, increase in index of psoriasis spreading and severity (PASI), relevant concentration of CD4+CD25+ bright and CD4+CD95+ lymphocytes. The genetic factor has no or little connection with the frequency of psoriasis relapse, development of such complicated forms of psoriasis as arthropathy and erythrodermatitis, biochemical markers of coagulative and anticoagulative systems, concentration of nitriteion (NO), the level of accumulation of lipid peroxidation products and antioxidant ferments activity, endogenous intoxication evidence and intensity.

Full Text

Связь наследственного фактора с клиническими, метаболическими и иммунологическими характеристиками больных псориазом

About the authors

O M Kapuler


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