The endothelium-dependent vasodilatation dysfunction during carrying out the test with fatty loading as the factor of coronary atherosclerosis in patients with a metabolic syndrome, the correction possibility with rosuvastatin

Influence of fatty meal during postprandial period on lipid spectrum and endothelium dysfunction on atherosclerosis of coronary vessels in patients with ischemic heart disease (IHD) and metabolic syndrome (MS) and correction of these factors with rosuvastatin was studied. It was shown that intake of food fats in IHD with MS and IHD with MS-free patients stimulated development of postprandial hyperlipemia of different severity and duration. In group 1 and 2 there was a definite and up to 6 hours in duration postprandial hypertriglyceridemia associated with growing of LDL cholesterol and lowering of HDL cholesterol. Index of endothelium function initially was depressed in all groups especially in gr. 1 and 2. Test with fatty loading led to vasospastic reaction, and decrease of endothelium function index in 2nd group was more prominent than in 1st group. So, the test of endothelium - dependent vasodilatation allows to allocate patients with more expressed injury of coronary vessels. Treatment with rosuvastatin (10 mg/day for 3 months) increased tolerance of the lipid-transport system to exogenous saturated fats and also increased index of endothelium function in postprandial period, defined by photoplethysmography.

ischemic heart disease, metabolic syndrome, postprandial hyperlipemia, fatty meal, endothelium - dependent vasodilatation, rosuvastatin