Safety of lipid-lowering pharmacotherapy in elderly patients with stable angina

Abstract


We estimated the safety of lipid-lowering pharmacotherapy in 248 elderly patients with stable angina. Rosuvastatin 10 mg/day with esetemib 10 mg/day was administrated to 81 pts of Group 1 with initial high LDL-level. Combination of atorvastatin 20 mg/day with esetemib 10 mg/day was administrated to 84 pts of Group 2 with moderate high LDL-level, while 83 pts of Group 3 with optimal LDL-level received simvastatin 40 mg/day. After 12 months of follow-up period we registered myalgia and/or myasthenia in 6 pts (2,4%), dyspepsia in 11 pts (4,4%) and increasing of transaminases in 9 pts (3,6%). In consideration of clinical significant events we interrupted the course of treatment in 4 pts (1,6%). The main causes among them were severe myalgia and/or myasthenia in 1 pt (0,4%), dyspepsia and gastrointestinal disorders in 3 pts (1,2%).

About the authors

I V Gagloeva

Email: simerzi@mail.ru

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