The antioxidant therapy of toxicity induced by transplantable carcinoma and irradiation

Abstract


The objective of the study was the investigation of the status of oxidative damage in rats with transplantable cholangiocellular RS-1 carcinoma. We investigated the ability of derivative LBK-149 oxinicotinic acid to control oxidative damage induced by tumor and irradiation. LBK-149 at a dose of 100 mg/kg was injected i.p. or i.m. before or after irradiation. Biochemical methods were used for this investigation. The greatest therapeutic efficiency has noted been at a combination LBK-149 after irradiation, in comparison with monoirradiation and preventive injection of a LBK-149. It was shown that injection LBK-149 (100 mg/kg) in 10 day after irradiation has allowed to increase a doze of irradiation up to 5 Gy without increase of level of oxidative damage.

About the authors

P I Skopin

Email: skopinpi@mail.ru

References

  1. Виноградов В.М. Перспективные методики лучевой терапии // Практическая онкология. - 2007. - т. 8. - № 4. - С. 194-203.
  2. Kumaraguruparan R., Subapriya R., Kabalimoorthy J., Nagini S. Antioxidant profile in the circulation of patients with fibroadenoma and adenocarcinoma of the breast // Clin. Biochem. - 2002. - vol. 35. - №4. - P. 275-279.
  3. Ladas E.J., Jacobson J.S., Kennedy D.D. et al. Antioxidants and cancer therapy: a systematic review // J. Clin. Oncol. - 2004. - vol. 1. - №22(3). - P. 517-528.
  4. Lawenda B.D., Kelly K.M., Ladas E.J. et al. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? // J. Natl. Cancer Inst. - 2008. - vol. 4. - №100(11). - P. 773-783.
  5. Prasad K.N., Cole W.C., Kumar B., Che Prasad K. Pros and cons of antioxidant use during radiation therapy // Cancer Treat. Rev. - 2002. - vol. 28. - №2. - P. 79-91.
  6. Roszkowski K., Gackowski D., Rozalski R. et al. Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism // Int. J. Cancer. - 2008. -vol. 15. - №123(8). - P. 1964-1967.
  7. Skrzydlewska E., Sulkowski S., Koda M. et al. Lipid peroxidation and antioxidant status in colorectal cancer // World J. Gastroenterol. - 2005. - vol. 21. - 11(3). - P. 403-406.

Statistics

Views

Abstract - 38

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c) 2010 Skopin P.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies