Email this article The antioxidant therapy of toxicity induced by transplantable carcinoma and irradiation
- Authors: Skopin PI1
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Affiliations:
- Issue: Vol 10, No 3-4 (2010)
- Pages: 236-239
- Section: Articles
- URL: https://aspvestnik.ru/2410-3764/article/view/25133
- DOI: https://doi.org/10.17816/2072-2354.2010.0.3-4.236-239
- ID: 25133
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Abstract
The objective of the study was the investigation of the status of oxidative damage in rats with transplantable cholangiocellular RS-1 carcinoma. We investigated the ability of derivative LBK-149 oxinicotinic acid to control oxidative damage induced by tumor and irradiation. LBK-149 at a dose of 100 mg/kg was injected i.p. or i.m. before or after irradiation. Biochemical methods were used for this investigation. The greatest therapeutic efficiency has noted been at a combination LBK-149 after irradiation, in comparison with monoirradiation and preventive injection of a LBK-149. It was shown that injection LBK-149 (100 mg/kg) in 10 day after irradiation has allowed to increase a doze of irradiation up to 5 Gy without increase of level of oxidative damage.
References
- Виноградов В.М. Перспективные методики лучевой терапии // Практическая онкология. - 2007. - т. 8. - № 4. - С. 194-203.
- Kumaraguruparan R., Subapriya R., Kabalimoorthy J., Nagini S. Antioxidant profile in the circulation of patients with fibroadenoma and adenocarcinoma of the breast // Clin. Biochem. - 2002. - vol. 35. - №4. - P. 275-279.
- Ladas E.J., Jacobson J.S., Kennedy D.D. et al. Antioxidants and cancer therapy: a systematic review // J. Clin. Oncol. - 2004. - vol. 1. - №22(3). - P. 517-528.
- Lawenda B.D., Kelly K.M., Ladas E.J. et al. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? // J. Natl. Cancer Inst. - 2008. - vol. 4. - №100(11). - P. 773-783.
- Prasad K.N., Cole W.C., Kumar B., Che Prasad K. Pros and cons of antioxidant use during radiation therapy // Cancer Treat. Rev. - 2002. - vol. 28. - №2. - P. 79-91.
- Roszkowski K., Gackowski D., Rozalski R. et al. Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism // Int. J. Cancer. - 2008. -vol. 15. - №123(8). - P. 1964-1967.
- Skrzydlewska E., Sulkowski S., Koda M. et al. Lipid peroxidation and antioxidant status in colorectal cancer // World J. Gastroenterol. - 2005. - vol. 21. - 11(3). - P. 403-406.
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