The peculiaritiesof the oxidation stress formationin erythrocytes in the patientswith chronic obstructionpulmonary disease


In 70 patients with COPD examined the change in the oxidant-antioxidant status of red blood cells, which form in these oxidative stress. In erythrocytes studied the content of malonic aldehyde, the activity of antioxidants: superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, glutathione reductase and glucose-6-phosphate dehydrogenase. Found that the intensity of oxidative stress in erythrocytes is directly dependent on the severity of the disease. In the group of patients with COPD and secondary erythrocytosis in contrast to patients without him against the backdrop of moderate oxidative stress observed maximum activity of antioxidant enzymes. Patients with stage III COPD is a significant accumulation in the membranes of red blood cells of secondary products of oxidative stress was associated with a sharp drop in activity of antioxidant systems. The data obtained allow to recommend the inclusion in the treatment of patients with COPD effective antioxidant agents.

About the authors

N A Mishina



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