Mexidol influenceon antimetastic activityof anticancer drugs

Abstract


The present study aimed to investigate the influence of combination of the synthetic
antioxidant mexidolum (3-oxy-6-metyl-2-etyl-piridin succinate) and antitumor drugs
- cyclophosphamide, 5-fluorouracil and rubomycine on cancer metastatic process. Studies
were performed on C57Bl mice which B16 melanoma had been implanted s.c. The volume
of primary tumor, quantity of lung surface metastases, ability to inhibit metastases were
determined. Mexidolum at a dose of 10 or 50 mg/kg body weight was injected i.m. daily
followed by tumor transplant for 25 days. Results showed that mexidolum significantly
increased antimetastatitic efficacy studied antitumor drugs.

About the authors

Pavel Igorevich Skopin

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