Mexidol influenceon antimetastic activityof anticancer drugs


The present study aimed to investigate the influence of combination of the synthetic
antioxidant mexidolum (3-oxy-6-metyl-2-etyl-piridin succinate) and antitumor drugs
- cyclophosphamide, 5-fluorouracil and rubomycine on cancer metastatic process. Studies
were performed on C57Bl mice which B16 melanoma had been implanted s.c. The volume
of primary tumor, quantity of lung surface metastases, ability to inhibit metastases were
determined. Mexidolum at a dose of 10 or 50 mg/kg body weight was injected i.m. daily
followed by tumor transplant for 25 days. Results showed that mexidolum significantly
increased antimetastatitic efficacy studied antitumor drugs.

About the authors

Pavel Igorevich Skopin


  1. Вершинина С.Ф., Потявина Е.В. Возможности онкологической фармакологии в свете идей профессора Н.В. Лазарева // Психофармакология и биологическая наркология. - 2005. - Т. 5, № 4. - С. 1096-1099.
  2. Руководство по химиотерапии опухолевых заболеваний / Под ред. Н.И. Переводчиковой. - 2-е изд., доп. М:.2005. 704 с.
  3. Albini A. Tumor microenvironment, a dangerous society leading to cancer metastasis. From mechanisms to therapy and prevention // Cancer Metastasis Rev. - 2008. - Vol. 27, №1. - P. 3-4.
  4. Block K.I., Koch A.C., Mead M.N., et al. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. // Int. J. Cancer. - 2008. -Vol. 15, №123(6). - P. 1227-1239.
  5. Buijs J.T., van der Pluijm G. Osteotropic cancers: from primary tumor to bone // Cancer Lett. - 2009. - Vol.18, №273(2). - P. 177-193.
  6. Guruvayoorappan C., Kuttan G. Effect of amentoflavone on the inhibition of pulmonary metastasis induced by B16F-10 melanoma cells in C57BL/6 mice // Integr. Cancer Ther. - 2007. - Vol.6, №2. - P. 185-197.
  7. Liu X., Chan S.Y., Ho P.C. Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma // Cancer Chemother. Pharmacol. - 2008. - Vol.63, №1. - P. 167-174.
  8. Ogasawara M., Matsunaga T., Suzuki H. Differential effects of antioxi-dants on the in vitro invasion, growth and lung metastasis of murine colon cancer cells // Biol. Pharm. Bull. - 2007. - Vol.30, № 1. - P. 200-204.
  9. Simone C.B. 2nd, Simone N.L., Simone V., Simone C.B. Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. // Altern. Ther. Health Med. - 2007. - Jan-Feb. vol. 13(1) - P. 22-28.



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